Brain synthetic magnetic resonance imaging and quantitative susceptibility mapping in patients with hepatitis B virus-related decompensated cirrhosis.

IF 2.9 2区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Hong Jin, Dongcui Wang, Ziyun Wang, Xun Ning, Wu Xing
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引用次数: 0

Abstract

Background: The traditional diagnostic methods for early hepatic encephalopathy (HE) detection involve certain limitations, including subjectivity and low sensitivity. This study aimed to integrate synthetic magnetic resonance imaging (SyMRI) and quantitative susceptibility mapping (QSM) techniques to examine the changes in quantitative parameter values of patients with hepatitis B virus-related (HBV-related) decompensated cirrhosis, with the goal of providing imaging-based evidence for early neurological symptoms and disease monitoring in patients with cirrhosis.

Methods: Data from 41 patients with HBV-related decompensated cirrhosis and 40 healthy controls were prospectively collected. T1 values, T2 values, proton density (PD) values, and magnetic susceptibility values of the bilateral frontal white matter, parietal white matter, occipital white matter, caudate nuclei, putamen, globus pallidus, thalamus, substantia nigra, red nuclei, and dentate nuclei were measured. Analysis of covariance (ANCOVA) was used to compare these values between the two groups. P values obtained were then corrected via the false-discovery rate (FDR) method. Correlation analysis was used to determine the correlation between the brain quantitative parameter values of patients and their clinical indicators.

Results: In the SyMRI study, patients with cirrhosis had significantly lower T1 values in the right frontal white matter (RFWM) (P=0.030), left frontal white matter (LFWM) (P=0.043), right parietal white matter (RPWM) (P=0.038), left parietal white matter (LPWM) (P=0.043), right occipital white matter (ROWM) (P=0.016), right caudate nuclei (P<0.001), left caudate nuclei (P=0.003), right putamen (RPUT) (P<0.001), left putamen (P<0.001), right globus pallidus (RGP) (P=0.007), right thalamus (RTHA) (P=0.044), right substantia nigra (RSN) (P=0.019), right dentate nuclei (P=0.033), and left dentate nuclei (P=0.016). Additionally, these patients had significantly lower T2 values in the RPUT (P=0.026), left putamen (P=0.043), RTHA (P=0.026), and left thalamus (LTHA) (P=0.016), along with significantly lower PD values in the RPWM (P=0.045), right caudate nuclei (P<0.001), left caudate nuclei (P<0.001), RPUT (P<0.001), left putamen (P<0.001), RTHA (P=0.016), right red nucleus (RRN) (P=0.016), and left red nucleus (LRN) (P=0.016). Moreover, the platelet count of patients was positively correlated with the T1 and PD values in the caudate nuclei (T1 right: r=0.451, P=0.030; T1 left: r=0.397, P=0.042; PD right: r=0.443, P=0.030; PD left: r=0.476 P=0.030) and putamen (T1 right: r=0.453, P=0.030; T1 left: r=0.400, P=0.042; PD right: r=0.463, P=0.030; PD left: r=0.510, P=0.026). In the QSM study, patients tended to exhibit an increase in magnetic susceptibility value in the ROWM and LTHA.

Conclusions: The measurement of T1 values, T2 values, PD values, and magnetic susceptibility values in deep gray-matter nuclei and white matter could contribute to the early warning of neurological symptoms and monitoring of disease progression in patients with HBV-related cirrhosis. Among these parameters, T1 and PD values may exhibit higher sensitivity as compared to magnetic susceptibility values.

乙型肝炎病毒相关失代偿性肝硬化患者的脑合成磁共振成像和定量易感性制图
背景:传统的肝性脑病(HE)早期诊断方法存在一定的局限性,包括主观性和低灵敏度。本研究旨在整合合成磁共振成像(SyMRI)和定量易感图谱(QSM)技术,探讨乙型肝炎病毒相关(hbv相关)失代偿性肝硬化患者定量参数值的变化,为肝硬化患者早期神经系统症状和疾病监测提供影像学依据。方法:前瞻性收集41例hbv相关失代偿性肝硬化患者和40例健康对照者的资料。测量双侧额叶白质、顶叶白质、枕叶白质、尾状核、壳核、苍白球、丘脑、黑质、红核、齿状核的T1值、T2值、质子密度(PD)值、磁化率值。采用协方差分析(ANCOVA)比较两组间的这些值。然后通过错误发现率(FDR)方法校正得到的P值。采用相关性分析确定患者脑定量参数值与其临床指标的相关性。结果:在SyMRI研究中,肝硬化患者在右侧额叶白质(RFWM) (P=0.030)、左侧额叶白质(LFWM) (P=0.043)、右侧顶叶白质(RPWM) (P=0.038)、左侧顶叶白质(LPWM) (P=0.043)、右侧枕叶白质(ROWM) (P=0.016)、右侧尾状核(P=0.016)的T1值均显著降低。测定深部灰质核和白质的T1值、T2值、PD值和磁化率值有助于hbv相关肝硬化患者神经系统症状的早期预警和疾病进展的监测。在这些参数中,T1和PD值可能比磁化率值具有更高的灵敏度。
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来源期刊
Quantitative Imaging in Medicine and Surgery
Quantitative Imaging in Medicine and Surgery Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
4.20
自引率
17.90%
发文量
252
期刊介绍: Information not localized
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