Design of a Mobile App and a Clinical Trial Management System for Cognitive Health and Dementia Risk Reduction: User-Centered Design Approach.

IF 5 Q1 GERIATRICS & GERONTOLOGY
JMIR Aging Pub Date : 2025-07-02 DOI:10.2196/66660
Hannes Hilberger, Bianca Buchgraber-Schnalzer, Simone Huber, Theresa Weitlaner, Markus Bödenler, Alara Abaci, Jeroen Bruinsma, Ana Diaz, Anna Giulia Guazzarini, Jenni Lehtisalo, Seungjune Lee, Vasileios Loukas, Francesca Mangialasche, Patrizia Mecocci, Tiia Ngandu, Anna Rosenberg, Elisabeth Stögmann, Konsta Valkonen, Elena Uhlik, Helena Untersteiner, Laura Kneß, Helmut Ahammer, Sten Hanke
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引用次数: 0

Abstract

Background: The rising prevalence of dementia is a major concern, with approximately 45% of cases linked to 14 modifiable risk factors. The European project LETHE aims to develop a personalized digital intervention model to delay or prevent cognitive decline through risk factor management.

Objective: The objective of our study was to design a clinical trial platform for older individuals at risk of cognitive decline, including a mobile app for study participants and a clinical trial management system (CTMS) for health professionals.

Methods: Using a user-centered design approach, workshops and feedback rounds involved potential participants representing the target group and professionals. The LETHE app's usability was assessed among 156 older adults enrolled in a 2-year multinational randomized controlled trial evaluating the feasibility of a digitally supported lifestyle program for dementia risk reduction. The randomized controlled trial is currently ongoing; the System Usability Scale (SUS) was administered 1 month after baseline to map first user experiences. Feedback on the LETHE CTMS was collected from 21 users.

Results: Of the 78 participants in the trial intervention group, 66 (85%) provided responses for the mobile app, with a median SUS score of 70 (IQR 55-82). Within the control group, 73% (57/78) of responses were received, with a median SUS score of 73 (IQR 63-90). For the CTMS, we received 71% (15/21) of responses, and the feedback was mostly positive. A ranking of the features that could be considered beyond state of the art showed that the integration of personalized activities (mean 2.23, SD 1.17) and real-time appointments (mean 2.46, SD 1.51) were considered the most novel ones.

Conclusions: The LETHE app and CTMS were developed to support a personalized digital intervention method within a study involving 156 participants. Limitations include participants having digital literacy and internet access, potentially impacting the generalizability of the findings. Despite these limitations, positive feedback and high usability scores suggest promising potential for the LETHE app and CTMS in supporting personalized interventions to prevent cognitive decline in older adults.

认知健康和痴呆风险降低的移动应用程序和临床试验管理系统的设计:以用户为中心的设计方法。
背景:痴呆症患病率的上升是一个主要问题,大约45%的病例与14个可改变的危险因素有关。欧洲LETHE项目旨在开发一种个性化的数字干预模式,通过风险因素管理来延缓或预防认知能力下降。目的:本研究的目的是为有认知能力下降风险的老年人设计一个临床试验平台,包括为研究参与者设计一个移动应用程序和为卫生专业人员设计一个临床试验管理系统(CTMS)。方法:采用以用户为中心的设计方法,让代表目标群体和专业人士的潜在参与者参与研讨会和反馈轮次。LETHE应用程序的可用性在156名老年人中进行了评估,这些老年人参加了一项为期两年的多国随机对照试验,以评估数字支持的生活方式项目降低痴呆症风险的可行性。该随机对照试验目前正在进行中;系统可用性量表(SUS)在基线后1个月进行,以绘制首次用户体验。收集了21位用户对LETHE CTMS的反馈意见。结果:在试验干预组的78名参与者中,66名(85%)对移动应用程序提供了回应,SUS得分中位数为70 (IQR 55-82)。在对照组中,收到73%(57/78)的应答,SUS评分中位数为73 (IQR 63-90)。对于CTMS,我们收到了71%(15/21)的反馈,反馈大多是积极的。一份可以被认为超越当前技术水平的功能排名显示,个性化活动(平均2.23,标准差1.17)和实时约会(平均2.46,标准差1.51)的整合被认为是最新颖的功能。结论:在一项涉及156名参与者的研究中,开发了LETHE应用程序和CTMS来支持个性化的数字干预方法。限制因素包括参与者具有数字素养和互联网接入,这可能会影响研究结果的普遍性。尽管存在这些限制,但积极的反馈和高可用性分数表明,LETHE应用程序和CTMS在支持个性化干预以预防老年人认知能力下降方面具有很大的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
JMIR Aging
JMIR Aging Social Sciences-Health (social science)
CiteScore
6.50
自引率
4.10%
发文量
71
审稿时长
12 weeks
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