Spontaneous T-cell lymphoblastic lymphoma in a young ICR mouse: a case report.

IF 0.9 4区医学 Q4 PATHOLOGY

Journal of Toxicologic Pathology Pub Date : 2025-07-01 Epub Date: 2025-03-13 DOI:10.1293/tox.2024-0086

Minkyoung Sung, Joo-Hee Choi, Soo-Eun Sung, Kyung-Ku Kang, Sun Hee Park, Duyeol Kim, Sijoon Lee

引用次数: 0

Abstract

Lymphoblastic lymphoma (LBL) is an aggressive neoplasm characterized by the proliferation of undifferentiated lymphocytes. It primarily spreads to immune organs such as the thymus, spleen, lymph nodes, bone marrow, and liver. Although well-documented in humans, spontaneous LBL cases in laboratory animals are exceedingly rare. This study reports a case of T cell-derived LBL in a young adult ICR mouse, notably without bone marrow metastasis. This case provides valuable insights into the spontaneous occurrence of LBL in laboratory rodents by contributing to comparative oncology and preclinical research.

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幼年ICR小鼠自发性t细胞淋巴母细胞淋巴瘤一例报告。

淋巴母细胞淋巴瘤（LBL）是一种侵袭性肿瘤，以未分化淋巴细胞增生为特征。它主要扩散到免疫器官，如胸腺、脾脏、淋巴结、骨髓和肝脏。虽然在人类中有充分的记录，但在实验动物中自发性LBL病例极为罕见。本研究报告了一例年轻成年ICR小鼠的T细胞源性LBL，特别是没有骨髓转移。本病例通过对比较肿瘤学和临床前研究的贡献，为实验室啮齿动物中LBL的自发发生提供了有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Toxicologic Pathology PATHOLOGY-TOXICOLOGY

CiteScore

2.10

自引率

16.70%

发文量

审稿时长

>12 weeks

期刊介绍： JTP is a scientific journal that publishes original studies in the field of toxicological pathology and in a wide variety of other related fields. The main scope of the journal is listed below. Administrative Opinions of Policymakers and Regulatory Agencies Adverse Events Carcinogenesis Data of A Predominantly Negative Nature Drug-Induced Hematologic Toxicity Embryological Pathology High Throughput Pathology Historical Data of Experimental Animals Immunohistochemical Analysis Molecular Pathology Nomenclature of Lesions Non-mammal Toxicity Study Result or Lesion Induced by Chemicals of Which Names Hidden on Account of the Authors Technology and Methodology Related to Toxicological Pathology Tumor Pathology; Neoplasia and Hyperplasia Ultrastructural Analysis Use of Animal Models.