DNA methylation studies in mouse models of depression: a systematic review.

IF 3 4区医学 Q2 GENETICS & HEREDITY

Epigenomics Pub Date : 2025-07-03 DOI:10.1080/17501911.2025.2525750

Mohammad Mustakim Billah, Chu Guo, Kazunari Mizuno, Yutaka Nakachi, Miki Bundo, Kazuya Iwamoto

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引用次数: 0

Abstract

Background: Major depression (MD) is caused by both genetic and environmental factors. Epigenetic mechanisms, particularly DNA methylation (5mC) and hydroxymethylation (5hmC), are thought to mediate gene - environment interactions. However, findings in mouse models remain dispersed.

Objective: This review evaluates the studies on 5mC and 5hmC in mouse models of depression.

Methods: We systematically searched PubMed, Scopus, and Web of Science using terms related to 5mC/5hmC, depression, and mouse, until December 2024. We grouped the articles as candidate, global, cellular, and comprehensive studies and summarized the findings accordingly.

Results: Sixty-eight studies met inclusion criteria. The main findings were environmental models, especially chronic stress paradigms, which were most frequently used to induce depression models. Candidate gene studies focused on Bdnf and Nr3c1, while global and cellular assays revealed both regional and widespread 5mC/5hmC changes. Genome-wide approaches revealed that epigenetic changes are not limited to isolated loci rather affect broad genomic regions involved in neural development and plasticity.

Conclusion: This review provides a comprehensive summary of existing research on epigenetic changes in terms of DNA methylation in mouse models of depression. Broader application of standardized, integrative, and cell-type-specific approaches is needed to fully elucidate the role of epigenetic regulation in the pathology of MD.

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抑郁症小鼠模型中的DNA甲基化研究：一项系统综述。

背景：重度抑郁症是遗传因素和环境因素共同作用的结果。表观遗传机制，特别是DNA甲基化（5mC）和羟甲基化（5hmC），被认为介导基因-环境相互作用。然而，在小鼠模型中的发现仍然分散。目的：综述抑郁症小鼠模型中5mC和5hmC的研究进展。方法：我们系统地检索PubMed， Scopus和Web of Science，使用与5mC/5hmC，抑郁症和小鼠相关的术语，直到2024年12月。我们将文章分为候选研究、整体研究、细胞研究和综合研究，并据此总结研究结果。结果：68项研究符合纳入标准。主要发现是环境模型，尤其是慢性压力范式，最常用于诱导抑郁模型。候选基因研究集中在Bdnf和Nr3c1上，而全球和细胞分析显示了区域和广泛的5mC/5hmC变化。全基因组方法表明，表观遗传变化并不局限于孤立的位点，而是影响涉及神经发育和可塑性的广泛基因组区域。结论：本文综述了抑郁症小鼠模型中DNA甲基化表观遗传变化的研究现状。为了充分阐明表观遗传调控在MD病理中的作用，需要更广泛地应用标准化、整合和细胞类型特异性的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Epigenomics GENETICS & HEREDITY-

CiteScore

5.80

自引率

2.60%

发文量

审稿时长

>12 weeks

期刊介绍： Epigenomics provides the forum to address the rapidly progressing research developments in this ever-expanding field; to report on the major challenges ahead and critical advances that are propelling the science forward. The journal delivers this information in concise, at-a-glance article formats – invaluable to a time constrained community. Substantial developments in our current knowledge and understanding of genomics and epigenetics are constantly being made, yet this field is still in its infancy. Epigenomics provides a critical overview of the latest and most significant advances as they unfold and explores their potential application in the clinical setting.