Renata Vargas, Adriana Pedreañez, Yenddy Carrero, Juan P Hernandez-Fonseca, Hugo Hernandez-Fonseca, Jesús A Mosquera
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引用次数: 0
Abstract
The expression of angiotensin II (Ang II) has been reported in diabetes associated with hypertension and inflammatory processes. It has also been reported a link between Ang II, depression and diabetes; however, underlying mechanisms of Ang II-induced depression in this disease remain unclear. This review focuses on the possible mechanisms of Ang II to induce depression in diabetes. Ang II can induce pro-inflammatory events that activate indoleamine 2,3-dioxygenase and kynurenine monooxygenase. These activated enzymes act by decreasing the production of serotonin and increasing the production of quinolinic acid which acts on the N-methyl-d-aspartate receptor and the amino-methyl propionic acid receptor inducing decreased brain-derived neurotrophic factor (BDNF) expression and depression. Ang II can also induce the production of galectin 3 which has a depressant effect. Neuroinflammation induced by Ang II during diabetes can alter brain cells, event associated with functional disorders and depression. Furthermore, Ang II is capable of inducing oxidative stress in diabetes linked to depressive behaviors. In conclusion, Ang II has the potential to induce depression during diabetes through different mechanisms that involve inflammatory processes, oxidative stress, the production of galectin 3, and decrease in serotonin and BDNF. These findings open the possibility of using anti-Ang II drugs for the treatment of depressive behavior in diabetes.
期刊介绍:
Diabetology International, the official journal of the Japan Diabetes Society, publishes original research articles about experimental research and clinical studies in diabetes and related areas. The journal also presents editorials, reviews, commentaries, reports of expert committees, and case reports on any aspect of diabetes. Diabetology International welcomes submissions from researchers, clinicians, and health professionals throughout the world who are interested in research, treatment, and care of patients with diabetes. All manuscripts are peer-reviewed to assure that high-quality information in the field of diabetes is made available to readers. Manuscripts are reviewed with due respect for the author''s confidentiality. At the same time, reviewers also have rights to confidentiality, which are respected by the editors. The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.