Epigenetic age acceleration and rheumatoid arthritis: an NHANES-based analysis and survival prediction models.

IF 4.8 2区医学 Q1 GENETICS & HEREDITY

Clinical Epigenetics Pub Date : 2025-07-02 DOI:10.1186/s13148-025-01919-8

Yuhang Ou, Zhihao Wang, Yunbo Yuan, Yuze He, Wenhao Li, Hao Ren, Junhong Li, Siliang Chen, Yanhui Liu

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引用次数: 0

Abstract

Objective: Epigenetic aging has been confirmed to be associated with the pathogenesis of rheumatoid arthritis (RA), however, its role in the prognosis of RA remains unclear.

Methods: In this cross-sectional and prospective study, Epigenetic age and acceleration in participants of the National Health and Nutrition Examination Survey (NHANES) were calculated with Horvath's clock, Hannum's clock, PhenoAge, GrimAge, and GrimAge version 2 (GrimAge2). The association of epigenetic age and epigenetic age acceleration with the prevalence and overall mortality risk in RA was assessed with prediction models constructed.

Results: Accelerated epigenetic aging increased the risk of overall mortality in RA with hazard ratio of 1.075 (95% CI 1.043-1.107, p < 0.0001) for GrimAge2 acceleration (GrimAge2Accel) and 1.064 (1.032-1.098, p < 0.0001) for GrimAge acceleration (GrimAgeAccel). The GrimAge2Accel-based models, adjusted for a set of covariates composed of independent risk factors, excelled in predicting the 10 year and 20 year survival with area under curve of 0.760 (95% CI 0.621-0.898) and 0.823 (0.697-0.949), respectively.

Conclusion: Epigenetic aging may play a harmfully promotive role in the onset and progression of RA, and the GrimAge2Accel-based prediction models could effectively predict the survival of RA patients. Further research is needed to elucidate the underlying mechanisms and to explore the potential clinical implications.

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表观遗传年龄加速和类风湿关节炎：基于nhanes的分析和生存预测模型。

目的：表观遗传衰老已被证实与类风湿关节炎（RA）的发病机制有关，但其在RA预后中的作用尚不清楚。方法：在这项横断面和前瞻性研究中，使用Horvath时钟、Hannum时钟、PhenoAge、GrimAge和GrimAge version 2 （GrimAge2）计算全国健康与营养检查调查（NHANES）参与者的表观遗传年龄和加速度。通过构建预测模型，评估表观遗传年龄和表观遗传年龄加速与RA患病率和总死亡风险的关系。结果：加速的表观遗传衰老增加了RA总死亡风险，风险比为1.075 （95% CI 1.043-1.107, p）。结论：表观遗传衰老可能在RA的发病和进展中起到有害的促进作用，基于grimage2accel的预测模型可以有效预测RA患者的生存。需要进一步的研究来阐明潜在的机制并探索潜在的临床意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Epigenetics ONCOLOGY-

自引率

5.30%

发文量

150

期刊介绍： Clinical Epigenetics, the official journal of the Clinical Epigenetics Society, is an open access, peer-reviewed journal that encompasses all aspects of epigenetic principles and mechanisms in relation to human disease, diagnosis and therapy. Clinical trials and research in disease model organisms are particularly welcome.