Association of Serum Thromboinflammatory Biomarkers With Atherosclerotic Plaques and Burden in a Community-Based Population.

IF 7.4 1区 医学 Q1 HEMATOLOGY
Baoshan Qiu, Xueli Cai, Lebo Zhou, Xuan Wang, Shan Li, Nan Wang, Lingling Jiang, Jing Jing, Tiemin Wei, Yongjun Wang, Yuesong Pan, Yilong Wang
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引用次数: 0

Abstract

Background: The pathogenesis of atherosclerosis involves complex mechanisms, with inflammation playing a central role. Thromboinflammation may contribute to its development and progression. We investigated the association between circulating thromboinflammatory biomarkers and atherosclerotic plaques.

Methods: Participants aged 50 to 75 years from the baseline survey of the PRECISE study (Polyvascular Evaluation for Cognitive Impairment and Vascular Events) were included. Serum levels of thromboinflammatory biomarkers (sGPVI [soluble glycoprotein VI]; sADAMTS13 [soluble a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13]; and sP-selectin) were assessed by ELISA and Luminex assays and categorized into quartiles based on their empirical distribution within the study population. Eligible participants underwent imaging using computed tomography angiography and magnetic resonance imaging for coronary atherosclerosis, intracranial atherosclerosis, and extracranial atherosclerosis, respectively.

Results: A total of 3019 participants (mean age, 61.20±6.68 years; 46.47% male) were analyzed. After multivariable adjustment, participants in the fourth quartile of sGPVI levels had higher odds of coronary atherosclerotic plaque burden (common odds ratio, 1.42 [95% CI, 1.14-1.76]; P=0.0017). Conversely, those in the highest sADAMTS13 quartile had lower odds of coronary plaques (odds ratio, 0.75 [95% CI, 0.60-0.93]; P=0.0094), as well as reduced coronary plaque burden, including segment involvement score (common odds ratio, 0.75 [95% CI, 0.61-0.93]; P=0.0087) and segment stenosis score (common odds ratio, 0.75 [95% CI, 0.61-0.93]; P=0.0086). No significant associations were observed between sGPVI or sADAMTS13 levels and intracranial or extracranial atherosclerosis. Likewise, after multivariable adjustment, no significant associations were observed between sP-selectin levels and coronary, intracranial, or extracranial atherosclerosis.

Conclusions: In our study, serum sADAMTS13 levels showed a negative association with both the presence and burden of coronary atherosclerosis, while sGPVI levels showed a positive association with the burden of coronary atherosclerosis. However, significant associations between the level of thromboinflammatory biomarkers, intracranial atherosclerosis, and extracranial atherosclerosis were not found.

血清血栓炎症生物标志物与社区人群动脉粥样硬化斑块和负担的关系
背景:动脉粥样硬化的发病机制复杂,炎症起核心作用。血栓炎症可能有助于其发展和进展。我们研究了循环血栓炎症生物标志物与动脉粥样硬化斑块之间的关系。方法:从PRECISE研究(认知障碍和血管事件的多血管评估)的基线调查中纳入年龄在50 - 75岁的参与者。血清血栓炎性生物标志物(sGPVI[可溶性糖蛋白VI]);sADAMTS13[可溶性a崩解素和金属蛋白酶与血小板反应蛋白1型基序,成员13];和sp -选择素)通过ELISA和Luminex检测进行评估,并根据其在研究人群中的经验分布将其分为四分位数。符合条件的参与者分别接受了冠状动脉粥样硬化、颅内动脉粥样硬化和颅外动脉粥样硬化的计算机断层血管造影和磁共振成像。结果:共纳入3019例受试者(平均年龄61.20±6.68岁;46.47%男性)。多变量调整后,sGPVI水平第四个四分位数的参与者冠状动脉粥样硬化斑块负担的几率更高(共同优势比,1.42 [95% CI, 1.14-1.76];P = 0.0017)。相反,sADAMTS13四分位数最高的患者发生冠状动脉斑块的几率较低(优势比为0.75 [95% CI, 0.60-0.93];P=0.0094),以及减少冠状动脉斑块负担,包括节段受累评分(共同优势比,0.75 [95% CI, 0.61-0.93];P=0.0087)和节段狭窄评分(共同优势比,0.75 [95% CI, 0.61-0.93];P = 0.0086)。sGPVI或sADAMTS13水平与颅内或颅外动脉粥样硬化之间无显著相关性。同样,在多变量调整后,sp -选择素水平与冠状动脉、颅内或颅外动脉粥样硬化之间没有显著关联。结论:在我们的研究中,血清sADAMTS13水平与冠状动脉粥样硬化的存在和负担呈负相关,而sGPVI水平与冠状动脉粥样硬化的负担呈正相关。然而,没有发现血栓炎性生物标志物水平与颅内动脉粥样硬化和颅外动脉粥样硬化之间的显著关联。
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来源期刊
CiteScore
15.60
自引率
2.30%
发文量
337
审稿时长
2-4 weeks
期刊介绍: The journal "Arteriosclerosis, Thrombosis, and Vascular Biology" (ATVB) is a scientific publication that focuses on the fields of vascular biology, atherosclerosis, and thrombosis. It is a peer-reviewed journal that publishes original research articles, reviews, and other scholarly content related to these areas. The journal is published by the American Heart Association (AHA) and the American Stroke Association (ASA). The journal was published bi-monthly until January 1992, after which it transitioned to a monthly publication schedule. The journal is aimed at a professional audience, including academic cardiologists, vascular biologists, physiologists, pharmacologists and hematologists.
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