Electrochemical Synthesis of Phosphorylated Glycine-Containing Oligopeptides

IF 4.7 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2025-07-03 DOI:10.1039/d5qo00803d

Jian Wang, You Huang, Yirui Shen, Fulai Li, Yufen Zhao, Ju Wu

引用次数: 0

Abstract

DABCO-mediated electrochemical synthesis of phosphorylated Glycine-containing oligopeptides has been developed, which eliminates the need for external oxidants. A series of di/tri/tetra/pentapeptides with different amino acid sequences were obtained in moderate to good yields under mild conditions. Remarkably, the synthetic applicability was further demonstrated through its easy scalability, and the in vitro cytotoxicity against HeLa, MDA-MB-231, HCT116 cells of the phosphorylated peptides was investigated.

查看原文本刊更多论文

含甘氨酸磷酸化寡肽的电化学合成

dabco介导的含甘氨酸寡肽的磷酸化电化学合成已被开发，该合成不需要外部氧化剂。在温和条件下，以中高产量获得了一系列不同氨基酸序列的二/三/四/五肽。值得注意的是，由于其易于扩展，进一步证明了其合成适用性，并研究了磷酸化肽对HeLa， MDA-MB-231， HCT116细胞的体外细胞毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.