The dark side of radiotherapy

IF 48.8 1区医学 Q1 CELL BIOLOGY

Cancer Cell Pub Date : 2025-07-03 DOI:10.1016/j.ccell.2025.06.008

András Piffkó, Sean P. Pitroda, Ralph R. Weichselbaum

引用次数: 0

Abstract

Radiotherapy (RT), while pivotal in cancer control, may paradoxically promote metastasis through systemic effects. Emerging evidence implicates RT-induced growth factors and immune modulation—especially via amphiregulin-epidermal growth factor receptor (EGFR) signaling—in facilitating metastatic outgrowth at distant sites. This effect underscores the need to refine RT strategies, identify high-risk patients, and explore therapeutic combinations targeting myeloid cells and EGFR pathways to mitigate pro-metastatic consequences and optimize outcomes in the immunotherapy era.

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放疗的阴暗面

放疗（RT）虽然在癌症控制中起关键作用，但可能矛盾地通过全身效应促进转移。新出现的证据表明，rt诱导的生长因子和免疫调节——特别是通过双调节因子表皮生长因子受体（EGFR）信号传导——促进了远处部位的转移。这一效应强调了在免疫治疗时代，需要改进RT策略，识别高风险患者，并探索针对骨髓细胞和EGFR通路的治疗组合，以减轻促转移后果并优化结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.