Malignant Transformation of Glioblastoma: One Step at a Time

IF 33.3 1区医学 Q1 ONCOLOGY

Cancer discovery Pub Date : 2025-07-03 DOI:10.1158/2159-8290.cd-25-0698

John J.Y. Lee, Mario L. Suvà

引用次数: 0

Abstract

Summary: In this issue of Cancer Discovery, Kim and colleagues characterize the transcriptional and epigenomic changes associated with gradual transformation of murine subventricular zone neural stem cells into glioblastoma, identifying an intermediary precancerous stage. Analysis of human glioblastoma and tumor-free subventricular zone tissues hints at the presence of precancerous cells with transcriptional similarity to murine precancerous cells and distinct aneuploidy from the bulk tumor. See related article by Kim et al., p. 1377

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胶质母细胞瘤的恶性转化：一步一步

摘要：在这一期的《癌症发现》杂志上，Kim及其同事描述了小鼠脑室下区神经干细胞逐渐转化为胶质母细胞瘤的转录和表观基因组变化，确定了中间癌前阶段。对人胶质母细胞瘤和无肿瘤的脑室下区组织的分析提示存在与小鼠癌前细胞转录相似的癌前细胞，并且与大块肿瘤具有明显的非整倍体。参见Kim等人的相关文章，第1377页

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer discovery ONCOLOGY-

CiteScore

22.90

自引率

1.40%

发文量

838

审稿时长

6-12 weeks

期刊介绍： Cancer Discovery publishes high-impact, peer-reviewed articles detailing significant advances in both research and clinical trials. Serving as a premier cancer information resource, the journal also features Review Articles, Perspectives, Commentaries, News stories, and Research Watch summaries to keep readers abreast of the latest findings in the field. Covering a wide range of topics, from laboratory research to clinical trials and epidemiologic studies, Cancer Discovery spans the entire spectrum of cancer research and medicine.