Expression and Prognostic Implication of the Nuclear Receptors Farnesoid X Receptor and Pregnane X Receptor in Human Cholangiocarcinoma.

Cancer diagnosis & prognosis Pub Date : 2025-06-30 eCollection Date: 2025-07-01 DOI:10.21873/cdp.10467
Prakasit Sa-Ngiamwibool, Kouichi Yoshinari, Ryota Shizu, Sarinya Kongpetch, Auemduan Prawan, Laddawan Senggunprai
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Abstract

Background/aim: Cumulative evidence reveals the contribution of nuclear receptors in the development and progression of cancers. The present study aimed to investigate the expression of two nuclear receptors, farnesoid X receptor (FXR) and pregnane X receptor (PXR), in cholangiocarcinoma (CCA) tissues and the correlation of their expression with clinicopathological features.

Materials and methods: FXR and PXR expression was evaluated in 111 resected CCA patient samples using immunohistochemistry, and the association of its expression with clinicopathological parameters was analyzed. The effectiveness of the expression of these nuclear receptors in predicting patients' outcomes was also assessed.

Results: FXR and PXR positivity was noted in all examined samples, with their expression predominantly localized in the cytoplasm. Patients with intraductal papillary neoplasm of the bile duct had significantly lower FXR expression (p=0.042). Elevated FXR expression was also significantly associated with lymph node metastasis (p=0.006) and advanced tumor stage (p=0.007). The results of the log-rank test analysis showed that the survival time of the patients was not associated with the expression of these two nuclear receptors. However, the CCA patients presenting low FXR/PXR expression tended to have a longer overall survival (p=0.125).

Conclusion: FXR may contribute to the progression of CCA to more advanced stages. The prognostic significance of FXR and PXR expression appears relevant in CCA. These nuclear receptors may have a function in the prediction and treatment of this deadly disease.

核受体法氏体X受体和孕烷X受体在人胆管癌中的表达及其预后意义。
背景/目的:越来越多的证据揭示了核受体在癌症发生和发展中的作用。本研究旨在探讨法氏体X受体(FXR)和孕烷X受体(PXR)两种核受体在胆管癌(CCA)组织中的表达及其与临床病理特征的相关性。材料与方法:应用免疫组化技术检测111例CCA患者标本中FXR和PXR的表达,并分析其表达与临床病理参数的关系。这些核受体表达在预测患者预后方面的有效性也被评估。结果:FXR和PXR在所有检测样本中均呈阳性,表达主要集中在细胞质中。胆管内乳头状肿瘤患者FXR表达明显降低(p=0.042)。FXR表达升高与淋巴结转移(p=0.006)和肿瘤分期(p=0.007)相关。log-rank检验分析结果显示,患者的生存时间与这两种核受体的表达无关。然而,FXR/PXR低表达的CCA患者总生存期较长(p=0.125)。结论:FXR可能促进CCA向晚期发展。FXR和PXR的表达对CCA的预后有重要意义。这些核受体可能在预测和治疗这种致命疾病中起作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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