5% benzoyl peroxide is the most efficient in reducing the cutibacterium flora of the shoulder skin: a network meta-analysis.

IF 4 2区医学 Q1 ORTHOPEDICS

Efort Open Reviews Pub Date : 2025-06-30 DOI:10.1530/EOR-2024-0160

Viktor Weninger, Gergely Agócs, Luca Hergár, Szilárd Váncsa, Bence Hegedűs, Imre Szerb, Péter Hegyi, Gábor Skaliczki

{"title":"5% benzoyl peroxide is the most efficient in reducing the cutibacterium flora of the shoulder skin: a network meta-analysis.","authors":"Viktor Weninger, Gergely Agócs, Luca Hergár, Szilárd Váncsa, Bence Hegedűs, Imre Szerb, Péter Hegyi, Gábor Skaliczki","doi":"10.1530/EOR-2024-0160","DOIUrl":null,"url":null,"abstract":"Purpose: Our study aims to compare different perioperative treatments to reduce C. acnes, the most common causative agent of surgical site infections following shoulder surgery.Methods: A systematic search was performed in MEDLINE (PubMed), Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), Scopus, and the Web of Science for studies published up to October 20, 2022. We included randomized-controlled trails investigating the efficacy of different dermal preparation in reducing the C. acnes colonising the skin surface. The studies examined positive bacterial cultures before and after skin treatment. The included trials were able to compare seven different skin treatment methods. We performed a frequentist network meta-analysis and calculated pooled risk ratios (RRs) with 95% confidence interval (CI).Results: Our study could include comparisons of 946 different patients. The use of 5% benzoyl peroxide (BPO) and its combination with the antibiotic clindamycin was found to be the most effective in reducing C. acnes colonization on the skin (BPO 5% RR = 0.25, CI: 0.08-0.72, BPO with clindamycin RR = 0.25, CI: 0.04-1.50). Based on the rank plot, 5% BPO (P score: 0.808) was the most effective treatment, followed by BPO 5% with clindamycin (P score: 0.749). We could not perform a network meta-analysis regarding the efficacy of different dermal preparation in reducing C. acnes colonization on the dermis and in the joint.Conclusion: Cutibacterium colonization of the skin flora can be effectively reduced on the skin surface by the use of 5% BPO.","PeriodicalId":48598,"journal":{"name":"Efort Open Reviews","volume":"10 7","pages":"543-550"},"PeriodicalIF":4.0000,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12232397/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Efort Open Reviews","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1530/EOR-2024-0160","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ORTHOPEDICS","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: Our study aims to compare different perioperative treatments to reduce C. acnes, the most common causative agent of surgical site infections following shoulder surgery.

Methods: A systematic search was performed in MEDLINE (PubMed), Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), Scopus, and the Web of Science for studies published up to October 20, 2022. We included randomized-controlled trails investigating the efficacy of different dermal preparation in reducing the C. acnes colonising the skin surface. The studies examined positive bacterial cultures before and after skin treatment. The included trials were able to compare seven different skin treatment methods. We performed a frequentist network meta-analysis and calculated pooled risk ratios (RRs) with 95% confidence interval (CI).

Results: Our study could include comparisons of 946 different patients. The use of 5% benzoyl peroxide (BPO) and its combination with the antibiotic clindamycin was found to be the most effective in reducing C. acnes colonization on the skin (BPO 5% RR = 0.25, CI: 0.08-0.72, BPO with clindamycin RR = 0.25, CI: 0.04-1.50). Based on the rank plot, 5% BPO (P score: 0.808) was the most effective treatment, followed by BPO 5% with clindamycin (P score: 0.749). We could not perform a network meta-analysis regarding the efficacy of different dermal preparation in reducing C. acnes colonization on the dermis and in the joint.

Conclusion: Cutibacterium colonization of the skin flora can be effectively reduced on the skin surface by the use of 5% BPO.

Abstract Image

查看原文本刊更多论文

5%过氧化苯甲酰是最有效的减少角质层菌群的肩部皮肤：网络荟萃分析。

目的：我们的研究旨在比较不同的围手术期治疗方法来减少痤疮，这是肩关节手术后手术部位感染最常见的病原体。方法：系统检索MEDLINE （PubMed）、Embase、Cochrane Central Register of Controlled Trials （Central）、Scopus和Web of Science，检索截至2022年10月20日发表的研究。我们纳入了随机对照试验，研究了不同的真皮制剂在减少痤疮C.在皮肤表面定植的功效。这些研究检查了皮肤治疗前后的阳性细菌培养。纳入的试验能够比较七种不同的皮肤治疗方法。我们进行了频率网络荟萃分析，并以95%置信区间（CI）计算了合并风险比（rr）。结果：我们的研究可能包括946名不同患者的比较。5%过氧化苯甲酰（BPO）与抗生素克林霉素联合使用对减少皮肤上痤疮C.定植最有效（BPO 5% RR = 0.25, CI: 0.08 ~ 0.72， BPO与克林霉素联合使用RR = 0.25, CI: 0.04 ~ 1.50）。从等级图上看，5% BPO （P评分：0.808）是最有效的治疗方法，其次是5% BPO联合克林霉素（P评分：0.749）。我们无法对不同真皮制剂在减少真皮和关节中痤疮芽胞杆菌定植方面的功效进行网络荟萃分析。结论：5% BPO可有效减少皮肤菌群在皮肤表面的定殖。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Efort Open Reviews Medicine-Orthopedics and Sports Medicine

CiteScore

6.60

自引率

2.90%

发文量

101

审稿时长

13 weeks

期刊介绍： EFORT Open Reviews publishes high-quality instructional review articles across the whole field of orthopaedics and traumatology. Commissioned, peer-reviewed articles from international experts summarize current knowledge and practice in orthopaedics, with the aim of providing systematic coverage of the field. All articles undergo rigorous scientific editing to ensure the highest standards of accuracy and clarity. This continuously published online journal is fully open access and will provide integrated CME. It is an authoritative resource for educating trainees and supports practising orthopaedic surgeons in keeping informed about the latest clinical and scientific advances. One print issue containing a selection of papers from the journal will be published each year to coincide with the EFORT Annual Congress. EFORT Open Reviews is the official journal of the European Federation of National Associations of Orthopaedics and Traumatology (EFORT) and is published in partnership with The British Editorial Society of Bone & Joint Surgery.