D A Evsyukov, Yu T Tsukanov, V P Dorofeeva, I O Snitko, M Kh Alikberov, A Yu Tsukanov
{"title":"[Varicose veins in chronic experiment].","authors":"D A Evsyukov, Yu T Tsukanov, V P Dorofeeva, I O Snitko, M Kh Alikberov, A Yu Tsukanov","doi":"10.17116/hirurgia202507116","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To create a method for modeling of varicose veins in dogs in a chronic experiment.</p><p><strong>Material and methods: </strong>The experiment was carried out on 15 sexually mature mongrel uncastrated male dogs weighing 15.000-17.000 g divided into 3 groups: group I (control) - human chorionic gonadotropin 200 U/kg and progesterone 1% 0.1 ml/kg intramuscularly; group II - hexestrol 0.09 mg/kg and progesterone 1% 0.1 ml /kg intramuscularly; group III - progesterone 1% 0.1 ml /kg intramuscularly. The drugs were administered 1 day before surgery. Then, we narrowed femoral vein in the upper third of the thigh under combined anesthesia. Intramuscular administration of the above-mentioned drugs was continued after surgery and for the next 6 days. Monitoring of ultrasound parameters and laboratory data (leukocytes, CRP, IL-6) was performed 1 day before surgery, after 10 and 30 days.</p><p><strong>Results: </strong>Femoral vein narrowing by ½ combined with progesterone and estrogen leads to staged development of varicose disease with persistent irreversible manifestations. Unlike groups 1 and 3, this combination is less associated with inflammatory response.</p><p><strong>Conclusion: </strong>A method for modeling of varicose veins in a chronic experiment was created.</p>","PeriodicalId":35986,"journal":{"name":"Khirurgiya","volume":" 7","pages":"16-23"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Khirurgiya","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17116/hirurgia202507116","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: To create a method for modeling of varicose veins in dogs in a chronic experiment.
Material and methods: The experiment was carried out on 15 sexually mature mongrel uncastrated male dogs weighing 15.000-17.000 g divided into 3 groups: group I (control) - human chorionic gonadotropin 200 U/kg and progesterone 1% 0.1 ml/kg intramuscularly; group II - hexestrol 0.09 mg/kg and progesterone 1% 0.1 ml /kg intramuscularly; group III - progesterone 1% 0.1 ml /kg intramuscularly. The drugs were administered 1 day before surgery. Then, we narrowed femoral vein in the upper third of the thigh under combined anesthesia. Intramuscular administration of the above-mentioned drugs was continued after surgery and for the next 6 days. Monitoring of ultrasound parameters and laboratory data (leukocytes, CRP, IL-6) was performed 1 day before surgery, after 10 and 30 days.
Results: Femoral vein narrowing by ½ combined with progesterone and estrogen leads to staged development of varicose disease with persistent irreversible manifestations. Unlike groups 1 and 3, this combination is less associated with inflammatory response.
Conclusion: A method for modeling of varicose veins in a chronic experiment was created.
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