Chongshun Zhao, Bo Liang, Xiaopeng Li, Peiheng Ma, Yiming Li, Zenghui Qian, Zhong Zhang, Tao Jiang, Wei Zhang
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引用次数: 0
Abstract
Background: Adult-type diffuse gliomas, particularly IDH-wildtype glioblastoma, exhibit significant differences in incidence across brain regions, with the occipital lobe being the rarest location. However, whether occipital glioblastoma differs from tumour in other regions in terms of prognosis and biological characteristics remains poorly understood.
Methods: This study included a total of 7,583 adult-type diffuse glioma patients from the SEER database, two public glioma datasets (UCSF-PDGM and UPENN-GBM), and a private dataset (Beijing Tiantan Hospital). For imaging data, Tumour location was classified using the USCLobes atlas, and white matter Tract Density Index (TDI) was computed to assess structural infiltration. Survival analyses employed Cox models and propensity score matching (PSM), adjusting for age, resection extent, and other confounders.
Results: The occipital lobe was the least common location for adult-type diffuse glioma (p < 0.001). Multivariable analysis adjusting for extent of resection and other confounders demonstrated that occipital tumours retained a significant survival advantage (adjusted HR = 0.82, 95% CI: 0.69-0.97, p = 0.019), corroborated in PSM cohorts (median OS 14 vs. 13 months, p = 0.012) and validated across independent datasets (HR = 0.73, 95% CI: 0.55-0.97, p = 0.027). Occipital glioblastoma exhibited lower TDI (p < 0.001).
Conclusion: Occipital glioblastoma represents a distinct clinical entity associated with improved survival outcomes. This survival advantage may be attributed to reduced white matter tract infiltration. Future research should focus on the differences in biological characteristics and treatment strategies of gliomas at different locations.
期刊介绍：
The Journal of Neuro-Oncology is a multi-disciplinary journal encompassing basic, applied, and clinical investigations in all research areas as they relate to cancer and the central nervous system. It provides a single forum for communication among neurologists, neurosurgeons, radiotherapists, medical oncologists, neuropathologists, neurodiagnosticians, and laboratory-based oncologists conducting relevant research. The Journal of Neuro-Oncology does not seek to isolate the field, but rather to focus the efforts of many disciplines in one publication through a format which pulls together these diverse interests. More than any other field of oncology, cancer of the central nervous system requires multi-disciplinary approaches. To alleviate having to scan dozens of journals of cell biology, pathology, laboratory and clinical endeavours, JNO is a periodical in which current, high-quality, relevant research in all aspects of neuro-oncology may be found.
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