Microbiome-based therapeutics towards healthier aging and longevity.

IF 10.4 1区生物学 Q1 GENETICS & HEREDITY

Genome Medicine Pub Date : 2025-07-01 DOI:10.1186/s13073-025-01493-x

Saurabh Kadyan, Gwoncheol Park, Tejinder P Singh, Cole Patoine, Saiful Singar, Teresa Heise, Christin Domeier, Chester Ray, Manoj Kumar, Pradip V Behare, Paramita Chakrabarty, Philip Efron, Julia Sheffler, Ravinder Nagpal

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引用次数: 0

Abstract

The gut microbiome is our lifetime companion, regulating our health from birth throughout the lifespan. The gut microbiome composition changes continually with age, influencing both physiological and immunological development. Emerging evidence highlights the close association, and thus implication, of the microbiome with healthy disease-free aging and longevity. Accordingly, targeting the gut microbiome is emerging as a promising avenue to prevent, alleviate, and ameliorate aging-related disorders. Herein, we provide a prospective and inclusive framework of the close connection of the gut microbiome with human aging, while contemplating how this association is intertwined with age-related diseases. We delve into recently emerging and potential microbiome-based therapeutics that are projected to aid in alleviating myriad aging-related diseases, thereby enhancing the health and well-being of the aging population. Finally, we present a foundation and perspective underlining the prospects of microbiome-based therapeutics developed and tailored precisely for the elderly, with the overarching goal of promoting health and longevity.

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基于微生物组的健康衰老和长寿疗法。

肠道微生物群是我们一生的伴侣，从出生到一生都在调节我们的健康。肠道菌群组成随着年龄的增长而不断变化，影响着生理和免疫发育。新出现的证据强调了微生物组与健康的无病衰老和长寿之间的密切联系，因此具有重要意义。因此，靶向肠道微生物组正在成为预防、缓解和改善衰老相关疾病的有希望的途径。在此，我们提供了肠道微生物组与人类衰老密切联系的前瞻性和包容性框架，同时考虑这种关联如何与年龄相关疾病交织在一起。我们深入研究了最近出现的和潜在的基于微生物组的治疗方法，这些治疗方法有望帮助缓解无数与衰老相关的疾病，从而增强老龄化人口的健康和福祉。最后，我们提出了一个基础和观点，强调了以促进健康和长寿为总体目标，为老年人开发和量身定制的基于微生物组的治疗方法的前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Genome Medicine GENETICS & HEREDITY-

CiteScore

20.80

自引率

0.80%

发文量

128

审稿时长

6-12 weeks

期刊介绍： Genome Medicine is an open access journal that publishes outstanding research applying genetics, genomics, and multi-omics to understand, diagnose, and treat disease. Bridging basic science and clinical research, it covers areas such as cancer genomics, immuno-oncology, immunogenomics, infectious disease, microbiome, neurogenomics, systems medicine, clinical genomics, gene therapies, precision medicine, and clinical trials. The journal publishes original research, methods, software, and reviews to serve authors and promote broad interest and importance in the field.