Oxidative stress - Alzheimer's disease - DNA methylation: the role of arsenic.

IF 5.6 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Daniele Antinori, Marco Lucarelli, Andrea Fuso
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引用次数: 0

Abstract

Alzheimer's disease (AD) is a neurodegenerative disease, representing the seventh cause of death worldwide and the first cause of dementia. Several pathogenic mechanisms have been connected to this pathology, including protein aggregation, oxidative stress, metabolic dysfunction, mitochondrial dysfunction, neuroinflammation, synaptic dysfunction, and cell death. The etiology of AD is multifactorial, suggesting that, in addition to a genetic component, the environment may strongly influence its onset and progression. Exposure to heavy metals, such as lead, cadmium, mercury, and arsenic (As), is known to be associated with AD, with As showing one of the strongest correlations, in relation to the epigenetic changes. The World Health Organization (WHO) set a very low limit for its concentration to 10 μg/l in drinking water. The possibility that As may induce epigenetic effects is a recent hypothesis. Evidence, so far, suggests that As may induce DNA hypomethylation in the brain, by mechanisms not yet completely disclosed. This minireview aims to provide evidence to support the role of As exposure in AD, maintaining a focus on oxidative stress and ferroptosis, with a perspective on DNA methylation.

氧化应激-阿尔茨海默病- DNA甲基化:砷的作用。
阿尔茨海默病(AD)是一种神经退行性疾病,是全球第七大死亡原因,也是痴呆症的第一大原因。几种致病机制与这种病理有关,包括蛋白质聚集、氧化应激、代谢功能障碍、线粒体功能障碍、神经炎症、突触功能障碍和细胞死亡。阿尔茨海默病的病因是多因素的,这表明,除了遗传因素外,环境可能强烈影响其发病和进展。已知暴露于重金属,如铅、镉、汞和砷(as)与AD有关,其中as与表观遗传变化的相关性最强。世界卫生组织(WHO)在饮用水中设定了极低的浓度限制,即每升10微克。As可能诱发表观遗传效应的可能性是最近提出的一种假说。到目前为止,有证据表明,As可能通过尚未完全揭示的机制诱导大脑中的DNA低甲基化。本综述旨在从DNA甲基化的角度,提供证据支持砷暴露在AD中的作用,保持对氧化应激和铁死亡的关注。
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来源期刊
Essays in biochemistry
Essays in biochemistry 生物-生化与分子生物学
CiteScore
10.50
自引率
0.00%
发文量
105
审稿时长
>12 weeks
期刊介绍: Essays in Biochemistry publishes short, digestible reviews from experts highlighting recent key topics in biochemistry and the molecular biosciences. Written to be accessible for those not yet immersed in the subject, each article is an up-to-date, self-contained summary of the topic. Bridging the gap between the latest research and established textbooks, Essays in Biochemistry will tell you what you need to know to begin exploring the field, as each article includes the top take-home messages as summary points. Each issue of the journal is guest edited by a key opinion leader in the area, and whether you are continuing your studies or moving into a new research area, the Journal gives a complete picture in one place. Essays in Biochemistry is proud to publish Understanding Biochemistry, an essential online resource for post-16 students, teachers and undergraduates. Providing up-to-date overviews of key concepts in biochemistry and the molecular biosciences, the Understanding Biochemistry issues of Essays in Biochemistry are published annually in October.
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