The biogenesis and biological roles of migrasomes in human diseases.

IF 7 2区生物学 Q1 CELL BIOLOGY

Cell Death Discovery Pub Date : 2025-07-01 DOI:10.1038/s41420-025-02569-8

Yifan Zhang, Wei Chen, Jiageng Zhu, Luwei Xu

{"title":"The biogenesis and biological roles of migrasomes in human diseases.","authors":"Yifan Zhang, Wei Chen, Jiageng Zhu, Luwei Xu","doi":"10.1038/s41420-025-02569-8","DOIUrl":null,"url":null,"abstract":"<p><p>Migrasomes are recently identified extracellular vesicles that are specifically generated by migrating cells. These pomegranate-like, membrane-bound organelles are released at the trailing edge during cell migration and play crucial roles in cell-to-cell communication, intercellular signaling, and tissue remodeling. Migrasomes selectively package various molecular components, including proteins, lipids, and RNA, facilitating a unique form of cellular communication known as migracytosis. They are involved in numerous physiological and pathological processes, including immune responses, cancer metastasis, tissue repair, and embryonic development. In this review, we provide an in-depth analysis of the biogenesis, structural features, and molecular composition of migrasomes. We further explore the emerging roles of migrasomes in disease pathogenesis, particularly their potential in cancer, neurodegenerative diseases, and immune modulation. Overall, this review aims to offer comprehensive insights into the latest research on migrasomes, while addressing the challenges in their study and potential avenues for future clinical implementation.</p>","PeriodicalId":9735,"journal":{"name":"Cell Death Discovery","volume":"11 1","pages":"296"},"PeriodicalIF":7.0000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12219052/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Death Discovery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41420-025-02569-8","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Migrasomes are recently identified extracellular vesicles that are specifically generated by migrating cells. These pomegranate-like, membrane-bound organelles are released at the trailing edge during cell migration and play crucial roles in cell-to-cell communication, intercellular signaling, and tissue remodeling. Migrasomes selectively package various molecular components, including proteins, lipids, and RNA, facilitating a unique form of cellular communication known as migracytosis. They are involved in numerous physiological and pathological processes, including immune responses, cancer metastasis, tissue repair, and embryonic development. In this review, we provide an in-depth analysis of the biogenesis, structural features, and molecular composition of migrasomes. We further explore the emerging roles of migrasomes in disease pathogenesis, particularly their potential in cancer, neurodegenerative diseases, and immune modulation. Overall, this review aims to offer comprehensive insights into the latest research on migrasomes, while addressing the challenges in their study and potential avenues for future clinical implementation.

查看原文本刊更多论文

偏头痛在人类疾病中的生物学发生和生物学作用。

迁移体是最近发现的由迁移细胞特异性产生的细胞外囊泡。这些石榴状的膜结合细胞器在细胞迁移过程中被释放在后缘，在细胞间通讯、细胞间信号传导和组织重塑中起着至关重要的作用。迁移小体选择性地包装各种分子成分，包括蛋白质、脂质和RNA，促进一种称为迁移细胞病的独特细胞通讯形式。它们参与了许多生理和病理过程，包括免疫反应、肿瘤转移、组织修复和胚胎发育。在这篇综述中，我们提供了深入的生物成因，结构特征和分子组成的迁移体分析。我们进一步探讨了偏头痛在疾病发病机制中的新角色，特别是它们在癌症、神经退行性疾病和免疫调节中的潜力。总的来说，本综述旨在全面了解偏头痛的最新研究，同时解决其研究中的挑战和未来临床实施的潜在途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Cell Death Discovery Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

8.30

自引率

1.40%

发文量

468

审稿时长

9 weeks

期刊介绍： Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research findings in Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death Discovery will build upon the success of Cell Death & Differentiation and Cell Death & Disease in publishing important peer-reviewed original research, timely reviews and editorial commentary. Cell Death Discovery is committed to increasing the reproducibility of research. To this end, in conjunction with its sister journals Cell Death & Differentiation and Cell Death & Disease, Cell Death Discovery provides a unique forum for scientists as well as clinicians and members of the pharmaceutical and biotechnical industry. It is committed to the rapid publication of high quality original papers that relate to these subjects, together with topical, usually solicited, reviews, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.