Efficacy and safety of platelet-rich plasma versus conventional care in diabetic foot ulcers: a meta-analysis of randomized controlled trials.

IF 2.9 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Acta Diabetologica Pub Date : 2025-07-02 DOI:10.1007/s00592-025-02555-7

Hongyan Xu, Kai Huang, Xiaohong Tao

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引用次数: 0

Abstract

Purpose: This meta-analysis aims to assess the efficacy and safety of platelet-rich plasma (PRP) through topical application and local injection methods compared to conventional care in patients with diabetic foot ulcers (DFU).

Methods: A comprehensive literature search was conducted across PubMed, Embase, and Web of Science databases up to November 2024. Randomized controlled trials evaluating the efficacy and safety of PRP versus conventional care in DFU patients were included. Pooled weighted mean differences (WMD) and risk ratios (RR) were calculated with 95% confidence intervals.

Results: Fifteen randomized controlled trials (1,010 patients) were included. The PRP group showed significantly improved complete healing rates compared to conventional care (RR: 1.53, 95% CI: 1.39-1.58, P < 0.001), with comparable effectiveness between topical application and local injection methods (P = 0.57). Notably, PRP demonstrated a shorter healing time compared to conventional care (WMD: -19.48 days, 95% CI: -27.91 to -11.05, P < 0.001). The PRP group exhibited lower wound infection rates and amputation rates (RR: 0.51, 95% CI: 0.35 to 0.75, P < 0.001; RR: 0.45, 95% CI: 0.26 to 0.79, P = 0.005). The PRP group did not lead to a higher incidence of treatment-related adverse events compared to conventional care (RR: 0.80, 95% CI: 0.05 to 12.30, P = 0.87).

Conclusions: This meta-analysis confirms that PRP application, both topically and via local injection, improves the complete healing rate, reduces healing time, infection rates, and amputations, without increasing adverse events. These findings support the integration of PRP into clinical practice for the management of diabetic foot ulcers.

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富血小板血浆治疗糖尿病足溃疡的疗效和安全性：一项随机对照试验的荟萃分析

目的：本荟萃分析旨在评估富血小板血浆（PRP）通过局部应用和局部注射方法与常规护理相比对糖尿病足溃疡（DFU）患者的疗效和安全性。方法：到2024年11月，在PubMed、Embase和Web of Science数据库中进行全面的文献检索。纳入随机对照试验，评估PRP与常规护理对DFU患者的疗效和安全性。以95%置信区间计算合并加权平均差（WMD）和风险比（RR）。结果：纳入15项随机对照试验（1010例患者）。与常规护理相比，PRP组的完全愈合率显著提高（RR: 1.53, 95% CI: 1.39-1.58， P）。结论：本荟萃分析证实，PRP应用，无论是局部注射还是局部注射，都能提高完全愈合率，缩短愈合时间，降低感染率和截肢率，且没有增加不良事件。这些发现支持将PRP纳入糖尿病足溃疡治疗的临床实践。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Diabetologica 医学-内分泌学与代谢

CiteScore

7.30

自引率

2.60%

发文量

180

审稿时长

2 months

期刊介绍： Acta Diabetologica is a journal that publishes reports of experimental and clinical research on diabetes mellitus and related metabolic diseases. Original contributions on biochemical, physiological, pathophysiological and clinical aspects of research on diabetes and metabolic diseases are welcome. Reports are published in the form of original articles, short communications and letters to the editor. Invited reviews and editorials are also published. A Methodology forum, which publishes contributions on methodological aspects of diabetes in vivo and in vitro, is also available. The Editor-in-chief will be pleased to consider articles describing new techniques (e.g., new transplantation methods, metabolic models), of innovative importance in the field of diabetes/metabolism. Finally, workshop reports are also welcome in Acta Diabetologica.