{"title":"Parallel Acceleration of Genome Variation Detection on Multi-Zone Heterogeneous System","authors":"Yaning Yang;Xiaoqi Wang;Chengqing Li;Shaoliang Peng","doi":"10.1109/TPDS.2025.3581972","DOIUrl":null,"url":null,"abstract":"Genomic variation is critical for understanding the genetic basis of disease. Pindel, a widely used structural variant caller, leverages short-read sequencing data to detect variation at single-base resolution; however, its hotspot module imposes substantial computational demands, limiting efficiency in large-scale whole-genome analyses. Heterogeneous architectures offer a promising solution, yet disparities in hardware design and programming models preclude direct porting of the original algorithm. To address this, we introduce MTPindel, a novel heterogeneous parallel optimization framework tailored to the MT-3000 processor. Focusing on Pindel’s most compute-intensive modules, we design multi-core and task-level parallel algorithms that exploit the MT-3000’s accelerator domains to balance and accelerate workload distribution. On 128 MT-3000–equipped nodes of the Tianhe next-generation supercomputer, MTPindel achieves an impressive 122.549 times of speedup and 95.74% parallel efficiency, with only a 0.74% error margin relative to the original implementation. This work represents a pioneering effort in heterogeneous parallelization for variant detection, paving the way for rapid, large-scale genomic analyses in research and clinical settings.","PeriodicalId":13257,"journal":{"name":"IEEE Transactions on Parallel and Distributed Systems","volume":"36 8","pages":"1797-1809"},"PeriodicalIF":5.6000,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"IEEE Transactions on Parallel and Distributed Systems","FirstCategoryId":"94","ListUrlMain":"https://ieeexplore.ieee.org/document/11045831/","RegionNum":2,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"COMPUTER SCIENCE, THEORY & METHODS","Score":null,"Total":0}
引用次数: 0
Abstract
Genomic variation is critical for understanding the genetic basis of disease. Pindel, a widely used structural variant caller, leverages short-read sequencing data to detect variation at single-base resolution; however, its hotspot module imposes substantial computational demands, limiting efficiency in large-scale whole-genome analyses. Heterogeneous architectures offer a promising solution, yet disparities in hardware design and programming models preclude direct porting of the original algorithm. To address this, we introduce MTPindel, a novel heterogeneous parallel optimization framework tailored to the MT-3000 processor. Focusing on Pindel’s most compute-intensive modules, we design multi-core and task-level parallel algorithms that exploit the MT-3000’s accelerator domains to balance and accelerate workload distribution. On 128 MT-3000–equipped nodes of the Tianhe next-generation supercomputer, MTPindel achieves an impressive 122.549 times of speedup and 95.74% parallel efficiency, with only a 0.74% error margin relative to the original implementation. This work represents a pioneering effort in heterogeneous parallelization for variant detection, paving the way for rapid, large-scale genomic analyses in research and clinical settings.
期刊介绍:
IEEE Transactions on Parallel and Distributed Systems (TPDS) is published monthly. It publishes a range of papers, comments on previously published papers, and survey articles that deal with the parallel and distributed systems research areas of current importance to our readers. Particular areas of interest include, but are not limited to:
a) Parallel and distributed algorithms, focusing on topics such as: models of computation; numerical, combinatorial, and data-intensive parallel algorithms, scalability of algorithms and data structures for parallel and distributed systems, communication and synchronization protocols, network algorithms, scheduling, and load balancing.
b) Applications of parallel and distributed computing, including computational and data-enabled science and engineering, big data applications, parallel crowd sourcing, large-scale social network analysis, management of big data, cloud and grid computing, scientific and biomedical applications, mobile computing, and cyber-physical systems.
c) Parallel and distributed architectures, including architectures for instruction-level and thread-level parallelism; design, analysis, implementation, fault resilience and performance measurements of multiple-processor systems; multicore processors, heterogeneous many-core systems; petascale and exascale systems designs; novel big data architectures; special purpose architectures, including graphics processors, signal processors, network processors, media accelerators, and other special purpose processors and accelerators; impact of technology on architecture; network and interconnect architectures; parallel I/O and storage systems; architecture of the memory hierarchy; power-efficient and green computing architectures; dependable architectures; and performance modeling and evaluation.
d) Parallel and distributed software, including parallel and multicore programming languages and compilers, runtime systems, operating systems, Internet computing and web services, resource management including green computing, middleware for grids, clouds, and data centers, libraries, performance modeling and evaluation, parallel programming paradigms, and programming environments and tools.