Exploring novel green synthetic pathways and recent advances in pyrrole and its derivatives

Abstract

Pyrrole has fascinated scientists since its first isolation in the 19th century, particularly due to its importance in natural compounds such as heme and chlorophyll. Its unique aromatic structure and diverse reactivity have established it as a key building block in both organic and medicinal chemistry. Over the years, the interest in pyrrole derivatives has grown, especially as researchers seek greener and more sustainable synthesis methods. This review examines the evolution of pyrrole chemistry, from traditional approaches to more modern, environmentally friendly techniques, including solvent-free reactions, microwave-assisted processes, and the utilization of renewable feedstocks. It explores the diverse range of biological activities exhibited by pyrrole-based molecules, including antimicrobial, anticancer, and neuroprotective effects. Additionally, the potential applications of pyrrole compounds extend beyond pharmaceuticals, reaching into materials science and electronics. The article concludes by identifying current research gaps and suggesting future directions that could advance pyrrole chemistry in alignment with green and sustainable development goals.