Copper-Catalyzed Stereo-Controllable Silylation of Allylic gem-Dichlorides

IF 4.6 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2025-07-02 DOI:10.1039/d5qo00690b

Zi-Lu Wang, Pan-Pan Tian, Yun-He Xu

引用次数: 0

Abstract

Herein, we present a ligand-regulated, stereo-controllable silylation reaction of allylic gem-dichlorides. In the absence of ligand, the reaction yields (Z)-vinyl chlorides with high stereoselectivity. Conversely, using a chiral Pybox ligand leads to the formation of (E)-vinyl chlorides with high enantioselectivity. This method demonstrates broad substrate compatibility, effectively producing the desired (Z)- and (E)-vinyl chloride products from a variety of aliphatic and aromatic allylic gem-dichlorides.

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铜催化烯丙基宝石二氯化物的立体可控硅基化

在这里，我们提出了一个配体调节的立体可控的烯丙基二氯宝石硅基化反应。在没有配体的情况下，反应生成立体选择性高的(Z)-氯乙烯。相反，使用手性Pybox配体可形成具有高对映选择性的(E)-乙烯氯化物。该方法证明了广泛的底物相容性，从各种脂肪族和芳香烯丙基宝石二氯化物中有效地生产所需的(Z)-和(E)-氯乙烯产品。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.