Tumor treating fields for glioblastoma: opportunities and drawbacks.

IF 2.7

Expert review of medical devices Pub Date : 2025-06-27 DOI:10.1080/17434440.2025.2526679

Alessandro Pesce, Mauro Palmieri, Alessandro Frati, Antonio Santoro, Maurizio Salvati

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Abstract

Introduction: Glioblastoma (GBM) stands as one of the most challenging malignancies to treat, with a prognosis that remains notably poor despite advancements in therapeutic strategies.

Areas covered: TTFields therapy is a novel approach to targeting cancer cell proliferation through alternating electric fields. The mechanism of action, dielectrophoresis, selectively disrupts mitotic processes in replicating cells, offering a localized treatment option with minimal systemic side effects.Clinical trials have demonstrated promising results, with TTFields therapy significantly improving progression-free and overall survival rates when combined with standard adjuvant treatments. However, questions regarding its impact on neuropsychological functioning and management of postoperative motor deficits remain unanswered.

Expert opinion: In conclusion, while TTFields therapy presents a valuable addition to GBM treatment modalities, further research is warranted to elucidate its full potential and address remaining challenges.

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胶质母细胞瘤的肿瘤治疗领域：机遇与缺点。

胶质母细胞瘤（GBM）是最具挑战性的恶性肿瘤之一，尽管治疗策略有所进步，但预后仍然很差。涉及领域：TTFields疗法是一种通过交变电场靶向癌细胞增殖的新方法。作用机制，电泳术，选择性地破坏复制细胞中的有丝分裂过程，提供了一种局部治疗选择，具有最小的全身副作用。临床试验已经证明了有希望的结果，与标准辅助治疗相结合，TTFields疗法显着提高了无进展和总生存率。然而，关于其对神经心理功能和术后运动缺陷管理的影响的问题仍然没有答案。专家意见：总之，虽然TTFields疗法是GBM治疗方式的一个有价值的补充，但需要进一步的研究来阐明其全部潜力并解决剩余的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Expert review of medical devices

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