Evaluating hormonal differences in post-orchidopexy patients: a meta-analysis of palpable vs. nonpalpable undescended testis.

IF 1.3 Q3 UROLOGY & NEPHROLOGY

Archivio Italiano di Urologia e Andrologia Pub Date : 2025-06-30 DOI:10.4081/aiua.2025.13903

Marshal Harvy Wicaksono Pantjoro, Anak Agung Ngurah Krisnanta Adnyana, Gede Wirya Kusuma Duarsa

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Abstract

Introduction: Cryptorchidism or undescended testis (UDT) is one of the most common congenital anomalies in male infants. Based on the physical examination, UDT can be classified into palpable and non-palpable. However, despite successful repositioning, the long-term function of the testis is still a concern. This meta-analysis aims to compare the testicular function of palpable UDT and non-palpable UDT post-orchidopexy using hormonal markers such as FSH, LH, and testosterone.

Materials and methods: A comprehensive literature search was performed using PubMed, ScienceDirect, and Google Scholar databases up to March 2025. Statistical analyses were conducted using Review Manager (RevMan).

Results: Four eligible studies were included in the analysis, involving 207 patients who underwent orchidopexy for UDT, including 160 with palpable UDT and 47 with non-palpable UDT. There is no significant difference between palpable compared to non-palpable in terms of FSH (MD 0.78 IU/L [95% CI: -0.34 to 1.90], p = 0.14); LH (MD -0.17 IU/L [95% CI: -0.45 to 0.12], p = 0.25); and testosterone (-0.08 IU/L [95% CI: -0.64 to 0.48], p = 0.78).

Conclusions: Testicular functions, including FSH, LH, and testosterone, in palpable UDT did not differ significantly from those in non-palpable UDT.

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评估睾丸切除术后患者的激素差异：可触及与不可触及的隐睾荟萃分析。

隐睾或睾丸不全（UDT）是男性婴儿最常见的先天性异常之一。根据体格检查，UDT可分为可触及和不可触及。然而，尽管成功地重新定位，睾丸的长期功能仍然是一个问题。本荟萃分析旨在比较睾丸切除术后可触及UDT和不可触及UDT的睾丸功能，使用激素标志物，如FSH、LH和睾酮。材料和方法：截至2025年3月，使用PubMed、ScienceDirect和谷歌Scholar数据库进行了全面的文献检索。使用Review Manager （RevMan）进行统计分析。结果：四项符合条件的研究纳入分析，涉及207例接受睾丸切除术治疗UDT的患者，其中160例可触及UDT， 47例不可触及UDT。可触及与不可触及的FSH无显著差异（MD 0.78 IU/L [95% CI: -0.34 ~ 1.90], p = 0.14）；LH (MD: -0.17 IU/L [95% CI: -0.45 ~ 0.12], p = 0.25)；睾酮（-0.08 IU/L [95% CI: -0.64 ~ 0.48], p = 0.78）。结论：可触及UDT患者的睾丸功能，包括FSH、LH和睾酮，与不可触及UDT患者无显著差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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