Does bilateral undescended testis have worst testicular function than unilateral cases? A meta-analysis of adult orchidopexy patients.

IF 1.3 Q3 UROLOGY & NEPHROLOGY

Archivio Italiano di Urologia e Andrologia Pub Date : 2025-06-30 DOI:10.4081/aiua.2025.13918

Anak Agung Ngurah Krisnanta Adnyana, Marshal Harvy Wicaksono Pantjoro, Gede Wirya Kusuma Duarsa

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Abstract

Introduction: Cryptorchidism, or undescended testis (UDT), is a congenital anomaly linked to an increased risk of infertility. The laterality of UDT, whether unilateral or bilateral, may influence post-orchidopexy outcomes. This meta-analysis compares testicular function and azoospermia rates between patients with bilateral and unilateral UDT post-orchiopexy.

Materials and methods: A comprehensive literature search was performed using PubMed, ScienceDirect, and Google Scholar databases up to March 2025. Statistical analyses were conducted using Review Manager (RevMan).

Results: Ten eligible studies were included in the analysis, comprising 563 bilateral UDT post-orchidopexy and 1259 unilateral UDT post-orchidopexy cases. Populations post bilateral orchidopexy have significantly higher FSH level (MD: 3.77 UI/L [95% CI: 1.65 - 5.89]), significantly higher LH level (MD: 1.27 UI/L [95% CI: 0.27 - 2.26]), lower inhibin B level (MD: -44.86 pg/mL [95% CI: -69.58 - -20.15]), and higher frequency of azoospermia (OR 2.3 [95% CI: 1.57 - 3.37]) compared to unilateral UDT post orchidopexy.

Conclusions: Bilateral UDT post-orchidopexy exhibits poorer testicular function with significantly higher FSH and LH levels, reduced inhibin B levels, and a greater incidence of azoospermia compared to unilateral UDT post-orchidopexy.

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双侧隐睾是否比单侧隐睾的睾丸功能更差？成人兰花切除术患者荟萃分析。

隐睾症，或称睾丸不降（UDT），是一种先天性异常，与不孕风险增加有关。UDT的偏侧性，无论是单侧还是双侧，都可能影响兰花切除术后的结果。本荟萃分析比较了双侧和单侧睾丸切除术后UDT患者的睾丸功能和无精子症发生率。材料和方法：截至2025年3月，使用PubMed、ScienceDirect和谷歌Scholar数据库进行了全面的文献检索。使用Review Manager （RevMan）进行统计分析。结果：10项符合条件的研究纳入分析，包括563例双侧UDT切除术后和1259例单侧UDT切除术后。与单侧睾丸切除术后的UDT相比，双侧睾丸切除术后的人群FSH水平显著升高（MD: 3.77 UI/L [95% CI: 1.65 - 5.89]）， LH水平显著升高（MD: 1.27 UI/L [95% CI: 0.27 - 2.26]），抑制素B水平较低（MD: -44.86 pg/mL [95% CI: -69.58 - -20.15]），无精子症发生率较高（OR 2.3 [95% CI: 1.57 - 3.37]）。结论：与单侧睾丸切除术后UDT相比，双侧UDT切除术后睾丸功能较差，FSH和LH水平明显升高，抑制素B水平降低，无精子症发生率更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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