A Comprehensive Systematic Review and Meta-Analysis to Unravel the Noise-Dementia Nexus.

IF 3.5 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

PUBLIC HEALTH REVIEWS Pub Date : 2025-06-16 eCollection Date: 2025-01-01 DOI:10.3389/phrs.2025.1607355

Soonmyung A Hwang, Aditi Singhvi, Lokesh Patil, Kimiya Gohari, Maayan Yitshak Sade, Elena Colicino, Melissa D Aldridge, Andrea A Baccarelli, Itai Kloog, Joel Schwartz, R Sean Morrison, Robert O Wright, Henrik Bøggild, Ali Sheidaei, Pablo Knobel

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引用次数: 0

Abstract

Objectives: As the aging population grows, Alzheimer's disease and related dementias (ADRD) present a major public health challenge. Environmental noise, linked to stress and sleep disruption, may increase ADRD risk. We aimed to summarize the research literature on long-term noise exposure and ADRD.

Methods: We conducted a systematic review and meta-analysis of studies investigating the association of long-term (≥1 year) noise exposure and ADRD assessed with standardized diagnostic criteria. Two reviewers independently screened studies, extracted data, and assessed risk of bias. Eligible studies reported hazard ratios (HR) or similar effect estimates with confidence intervals.

Results: A multilevel random-effects meta-analysis of six longitudinal studies using 13 effect sizes found a significant association between long-term noise exposure and incident ADRD (HR: 1.15, 95% CI: 1.03-1.28). Interaction effects between noise source and dementia subtype were not statistically significant.

Conclusion: Long-term noise exposure may contribute to ADRD risk. Heterogeneity between studies highlights the need for standardized exposure assessment and consideration of other environmental factors. Future research should include the exposome approach for identifying environmental drivers of dementia.

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一项全面的系统综述和荟萃分析来揭示噪音与痴呆的关系。

随着人口老龄化的增长，阿尔茨海默病和相关痴呆（ADRD）提出了一个重大的公共卫生挑战。与压力和睡眠中断有关的环境噪音可能会增加ADRD的风险。本文旨在对长期噪声暴露与adr的研究文献进行综述。方法：我们对调查长期（≥1年）噪声暴露与ADRD之间关系的研究进行了系统回顾和荟萃分析，并采用标准化诊断标准进行了评估。两位审稿人独立筛选研究、提取数据并评估偏倚风险。符合条件的研究报告了风险比（HR）或具有置信区间的类似效应估计。结果：使用13种效应大小的6项纵向研究的多水平随机效应荟萃分析发现，长期噪声暴露与事件ADRD之间存在显著关联（HR: 1.15, 95% CI: 1.03-1.28）。噪声源与痴呆亚型之间的交互作用无统计学意义。结论：长期噪声暴露可能增加ADRD风险。研究之间的异质性突出了标准化暴露评估和考虑其他环境因素的必要性。未来的研究应该包括确定痴呆的环境驱动因素的暴露方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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