Optical theranostics in ischemic heart disease: from molecular insights to clinical translation.

IF 12.4 1区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Theranostics Pub Date : 2025-06-09 eCollection Date: 2025-01-01 DOI:10.7150/thno.114307
Yangjie Xiao, Jing Zhang, Lu Sun, Ke Wang, Yan Chen, Qiaojin Zheng, Ying Li
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引用次数: 0

Abstract

Accurate risk stratification of ischemic heart disease (IHD) remains pivotal for mitigating associated global health burdens. Optical theranostics, combining imaging and therapeutic capabilities through light-based technologies, has emerged as a transformative strategy for IHD management. Advanced modalities mainly including optical coherence tomography, near-infrared fluorescence imaging, and photoacoustic imaging enable high-resolution visualization of coronary anatomy, myocardial perfusion, and molecular biomarkers. These modalities complement traditional cardiovascular imaging by providing real-time functional and molecular data with enhanced spatial resolution. Concurrently, phototherapy strategies such as image-guided photodynamic and photothermal therapies show therapeutic potential in preclinical studies. Integrated theranostic platforms now operationalize closed-loop workflows, where diagnostic imaging directly informs therapeutic parameters and monitors treatment response. While challenges persist in clinical translation-including tissue penetration limitations and safety optimization-ongoing developments in contrast agents, device miniaturization, and multimodal integration are accelerating practical applications. This review examines current progress in optical theranostics for IHD, analyzing technical principles, preclinical/clinical implementations, and translational barriers to optimize cardiovascular care through light-based technologies.

缺血性心脏病的光学治疗:从分子认识到临床转化。
缺血性心脏病(IHD)的准确风险分层仍然是减轻相关全球健康负担的关键。光学治疗通过基于光的技术结合成像和治疗能力,已经成为IHD管理的一种变革性战略。先进的成像技术主要包括光学相干断层扫描、近红外荧光成像和光声成像,能够实现冠状动脉解剖、心肌灌注和分子生物标志物的高分辨率可视化。这些模式通过提供实时功能和分子数据,增强了空间分辨率,补充了传统的心血管成像。同时,光疗策略,如图像引导光动力和光热疗法在临床前研究中显示出治疗潜力。集成治疗平台现在实现了闭环工作流程,其中诊断成像直接通知治疗参数并监测治疗反应。尽管在临床翻译中仍然存在挑战,包括组织渗透限制和安全性优化,但造影剂、设备小型化和多模式集成的持续发展正在加速实际应用。本文综述了目前IHD光学治疗的进展,分析了通过光基技术优化心血管护理的技术原理、临床前/临床实施和转化障碍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Theranostics
Theranostics MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
25.40
自引率
1.60%
发文量
433
审稿时长
1 months
期刊介绍: Theranostics serves as a pivotal platform for the exchange of clinical and scientific insights within the diagnostic and therapeutic molecular and nanomedicine community, along with allied professions engaged in integrating molecular imaging and therapy. As a multidisciplinary journal, Theranostics showcases innovative research articles spanning fields such as in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensor technology, nanobiosensors, bioelectronics, system biology, translational medicine, point-of-care applications, and personalized medicine. Encouraging a broad spectrum of biomedical research with potential theranostic applications, the journal rigorously peer-reviews primary research, alongside publishing reviews, news, and commentary that aim to bridge the gap between the laboratory, clinic, and biotechnology industries.
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