Genesis of similar collective states in DNA molecules under various viscosity of the medium and external torque.

Abstract

The nucleotide sequence determines the structural properties of B-DNA; this fact is considered key in recognizing protein binding sites and changing its activity. Our study has established that, using an angular mathematical model, it is possible to determine areas of similar collective states and bends in the nucleotide sequence that arise even under small torque influences. Calculations were performed for two genes that differ slightly in length (B2M and fragment of the Drosophila gene to compare). The dependence of the formation of similar collective states on the viscosity of the medium and the magnitude of the external torque effect was established. The work also found that for different genes, bending zones are observed in different parts of the genes, which confirms the dependence of the rigidity of the area on the nucleotide sequence and correlates with known data.