The Impact of Metabolic Syndrome on Immune Regulation (IL-17, IL-23, and FOXP3+), Psoriasis Severity, Flare Frequency, and Quality of Life in Psoriasis Patients: A Cross-Sectional Study.

IF 2 Q3 IMMUNOLOGY
International Journal of Inflammation Pub Date : 2025-06-20 eCollection Date: 2025-01-01 DOI:10.1155/ijin/5855171
Flora Ramona Sigit Prakoeswa, Faradiba Maharani, Saiful Hidayat, Winda Atika Sari, Triasari Oktavriana, Cita Rosita Sigit Prakoeswa, Menul Ayu Umborowati, Ratih Pramuningtyas, Rochmadina Suci Bestari, Riandini Aisyah, Erika Diana Risanti, Listiana Masyita Dewi, Ilham Hafizha Maulana Anam
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Abstract

Introduction: Psoriasis is a chronic inflammatory skin disease that exhibits a strong association with metabolic syndrome (MetS). The involvement of various proinflammatory cytokines in MetS is thought to play a critical role in the pathogenesis of psoriasis. This study aims to evaluate the impact of MetS on immunological markers (IL-17, IL-23, and FOXP3+ regulatory T cells), disease severity, and quality of life (QoL) among patients with psoriasis. Methods: This cross-sectional study involved 42 psoriasis patients, divided into two groups: 29 without MetS (Pso) and 13 with MetS (Pso-MetS). Clinical parameters such as blood pressure, fasting blood glucose, and triglyceride levels were measured. Immunological markers (IL-17, IL-23, and FOXP3+) were analyzed using ELISA. Psoriasis severity was assessed using the Psoriasis Area and Severity Index (PASI), and QoL was evaluated with the Dermatology Life Quality Index (DLQI). Results: The Pso-MetS group was significantly older than the Pso group (p value = 0.003). Higher systolic (p value < 0.001), fasting glucose (p value = 0.002), and triglycerides (p value < 0.001) were observed in the Pso-MetS group. Lower HDL observed in the Pso-MetS group (p value = 0.004). FOXP3+ expression was significantly lower in the Pso-MetS group (p=0.02), while waist circumference, diastolic blood pressure, IL-17, IL-23, PASI, and DLQI scores levels showed no significant differences. Conclusions: MetS is associated with immune dysregulation, evidenced by reduced FOXP3+ expression in psoriasis patients. Further studies are needed to explore the immunological link between psoriasis and MetS.

代谢综合征对银屑病患者免疫调节(IL-17、IL-23和FOXP3+)、银屑病严重程度、发作频率和生活质量的影响:一项横断面研究
简介:银屑病是一种慢性炎症性皮肤病,与代谢综合征(MetS)密切相关。各种促炎细胞因子参与MetS被认为在牛皮癣的发病机制中起关键作用。本研究旨在评估MetS对银屑病患者免疫标志物(IL-17、IL-23和FOXP3+调节性T细胞)、疾病严重程度和生活质量(QoL)的影响。方法:本横断面研究纳入42例银屑病患者,分为两组:29例无MetS (Pso)和13例有MetS (Pso-MetS)。临床参数如血压、空腹血糖和甘油三酯水平被测量。ELISA法检测免疫标志物(IL-17、IL-23、FOXP3+)。采用银屑病面积及严重程度指数(PASI)评价银屑病严重程度,采用皮肤病生活质量指数(DLQI)评价生活质量。结果:Pso- mets组明显大于Pso组(p值= 0.003)。Pso-MetS组的收缩压(p值< 0.001)、空腹血糖(p值= 0.002)和甘油三酯(p值< 0.001)升高。Pso-MetS组HDL降低(p值= 0.004)。Pso-MetS组FOXP3+表达显著降低(p=0.02),而腰围、舒张压、IL-17、IL-23、PASI、DLQI评分水平差异无统计学意义。结论:银屑病患者FOXP3+表达降低证明了MetS与免疫失调有关。银屑病与MetS之间的免疫学联系有待进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.80
自引率
0.00%
发文量
16
审稿时长
16 weeks
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