Biological significance of extracellular vesicles in innate immune system.

IF 2.8 4区 医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Innate Immunity Pub Date : 2025-01-01 Epub Date: 2025-06-30 DOI:10.1177/17534259251355029
Budjav Jadamba, Jihye Park, Heedoo Lee
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引用次数: 0

Abstract

Extracellular vesicles (EVs), which are nanosized membranous structures released by diverse cell types, serve as crucial mediators of intercellular communication. Recent evidence has highlighted the dynamic transfer of various biological components, including proteins, lipids, mRNAs, non-coding RNAs, miRNAs, and DNA, via EVs. Immuno-stimulated cells actively release EVs that play a pivotal role in regulating the innate immune system. This study comprehensively reviews the current scientific findings, shedding light on the intricate biological roles of EVs in regulating innate immune cells and the overall immune system. This discussion encompasses diverse pathophysiological conditions and provides valuable insights into the multifaceted contributions of EVs to innate immune responses.

细胞外囊泡在先天免疫系统中的生物学意义。
细胞外囊泡(EVs)是由多种细胞类型释放的纳米级膜状结构,是细胞间通讯的重要介质。最近的证据强调了各种生物成分的动态转移,包括蛋白质、脂质、mrna、非编码rna、mirna和DNA,通过电动汽车。免疫刺激细胞主动释放在调节先天免疫系统中起关键作用的ev。本研究全面回顾了目前的科学发现,揭示了ev在调节先天免疫细胞和整体免疫系统中的复杂生物学作用。这一讨论涵盖了多种病理生理条件,并为ev对先天免疫反应的多方面贡献提供了有价值的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Innate Immunity
Innate Immunity 生物-免疫学
CiteScore
7.20
自引率
0.00%
发文量
20
审稿时长
6-12 weeks
期刊介绍: Innate Immunity is a highly ranked, peer-reviewed scholarly journal and is the official journal of the International Endotoxin & Innate Immunity Society (IEIIS). The journal welcomes manuscripts from researchers actively working on all aspects of innate immunity including biologically active bacterial, viral, fungal, parasitic, and plant components, as well as relevant cells, their receptors, signaling pathways, and induced mediators. The aim of the Journal is to provide a single, interdisciplinary forum for the dissemination of new information on innate immunity in humans, animals, and plants to researchers. The Journal creates a vehicle for the publication of articles encompassing all areas of research, basic, applied, and clinical. The subject areas of interest include, but are not limited to, research in biochemistry, biophysics, cell biology, chemistry, clinical medicine, immunology, infectious disease, microbiology, molecular biology, and pharmacology.
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