{"title":"Thin-slice T<sub>2</sub>-weighted images and deep-learning-based super-resolution reconstruction: improved preoperative assessment of vascular invasion for pancreatic ductal adenocarcinoma.","authors":"Xiaoqi Zhou, Yuxin Wu, Yanjin Qin, Chenyu Song, Meng Wang, Huasong Cai, Qiaochu Zhao, Jiawei Liu, Jifei Wang, Zhi Dong, Yanji Luo, Zhenpeng Peng, Shi-Ting Feng","doi":"10.1186/s13244-025-02022-5","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the efficacy of thin-slice T<sub>2</sub>-weighted imaging (T<sub>2</sub>WI) and super-resolution reconstruction (SRR) for preoperative assessment of vascular invasion in pancreatic ductal adenocarcinoma (PDAC).</p><p><strong>Methods: </strong>Ninety-five PDACs with preoperative MRI were retrospectively enrolled as a training set, with non-reconstructed T<sub>2</sub>WI (NRT<sub>2</sub>) in different slice thicknesses (NRT<sub>2</sub>-3, 3 mm; NRT<sub>2</sub>-5, ≥ 5 mm). A prospective test set was collected with NRT<sub>2</sub>-5 (n = 125) only. A deep-learning network was employed to generate reconstructed super-resolution T<sub>2</sub>WI (SRT<sub>2</sub>) in different slice thicknesses (SRT<sub>2</sub>-3, 3 mm; SRT<sub>2</sub>-5, ≥ 5 mm). Image quality was assessed, including the signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and signal-intensity ratio (SIR<sub>t/p</sub>, tumor/pancreas; SIR<sub>t/b</sub>, tumor/background). Diagnostic efficacy for vascular invasion was evaluated using the area under the curve (AUC) and compared across different slice thicknesses before and after reconstruction.</p><p><strong>Results: </strong>SRT<sub>2</sub>-5 demonstrated higher SNR and SIR<sub>t/p</sub> compared to NRT<sub>2</sub>-5 (74.18 vs 72.46; 1.42 vs 1.30; p < 0.05). SRT<sub>2</sub>-3 showed increased SIR<sub>t/p</sub> and SIR<sub>t/b</sub> over NRT<sub>2</sub>-3 (1.35 vs 1.31; 2.73 vs 2.58; p < 0.05). SRT<sub>2</sub>-5 showed higher CNR, SIR<sub>t/p</sub> and SIR<sub>t/b</sub> than NRT<sub>2</sub>-3 (p < 0.05). NRT<sub>2</sub>-3 outperformed NRT<sub>2</sub>-5 in evaluating venous invasion (AUC: 0.732 vs 0.597, p = 0.021). SRR improved venous assessment (AUC: NRT<sub>2</sub>-3, 0.927 vs 0.732; NRT<sub>2</sub>-5, 0.823 vs 0.597; p < 0.05), and SRT<sub>2</sub>-5 exhibits comparable efficacy to NRT<sub>2</sub>-3 in venous assessment (AUC: 0.823 vs 0.732, p = 0.162).</p><p><strong>Conclusion: </strong>Thin-slice T<sub>2</sub>WI and SRR effectively improve the image quality and diagnostic efficacy for assessing venous invasion in PDAC. Thick-slice T<sub>2</sub>WI with SRR is a potential alternative to thin-slice T<sub>2</sub>WI.</p><p><strong>Critical relevance statement: </strong>Both thin-slice T<sub>2</sub>-WI and SRR effectively improve image quality and diagnostic performance, providing valuable options for optimizing preoperative vascular assessment in PDAC. Non-invasive and accurate assessment of vascular invasion supports treatment planning and avoids futile surgery.</p><p><strong>Key points: </strong>Vascular invasion evaluation is critical for the surgical eligibility of PDAC. SRR improved image quality and vascular assessment in T<sub>2</sub>WI. Utilizing thin-slice T<sub>2</sub>WI and SRR aids in clinical decision making for PDAC.</p>","PeriodicalId":13639,"journal":{"name":"Insights into Imaging","volume":"16 1","pages":"144"},"PeriodicalIF":4.1000,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Insights into Imaging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s13244-025-02022-5","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose: To evaluate the efficacy of thin-slice T2-weighted imaging (T2WI) and super-resolution reconstruction (SRR) for preoperative assessment of vascular invasion in pancreatic ductal adenocarcinoma (PDAC).
Methods: Ninety-five PDACs with preoperative MRI were retrospectively enrolled as a training set, with non-reconstructed T2WI (NRT2) in different slice thicknesses (NRT2-3, 3 mm; NRT2-5, ≥ 5 mm). A prospective test set was collected with NRT2-5 (n = 125) only. A deep-learning network was employed to generate reconstructed super-resolution T2WI (SRT2) in different slice thicknesses (SRT2-3, 3 mm; SRT2-5, ≥ 5 mm). Image quality was assessed, including the signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and signal-intensity ratio (SIRt/p, tumor/pancreas; SIRt/b, tumor/background). Diagnostic efficacy for vascular invasion was evaluated using the area under the curve (AUC) and compared across different slice thicknesses before and after reconstruction.
Results: SRT2-5 demonstrated higher SNR and SIRt/p compared to NRT2-5 (74.18 vs 72.46; 1.42 vs 1.30; p < 0.05). SRT2-3 showed increased SIRt/p and SIRt/b over NRT2-3 (1.35 vs 1.31; 2.73 vs 2.58; p < 0.05). SRT2-5 showed higher CNR, SIRt/p and SIRt/b than NRT2-3 (p < 0.05). NRT2-3 outperformed NRT2-5 in evaluating venous invasion (AUC: 0.732 vs 0.597, p = 0.021). SRR improved venous assessment (AUC: NRT2-3, 0.927 vs 0.732; NRT2-5, 0.823 vs 0.597; p < 0.05), and SRT2-5 exhibits comparable efficacy to NRT2-3 in venous assessment (AUC: 0.823 vs 0.732, p = 0.162).
Conclusion: Thin-slice T2WI and SRR effectively improve the image quality and diagnostic efficacy for assessing venous invasion in PDAC. Thick-slice T2WI with SRR is a potential alternative to thin-slice T2WI.
Critical relevance statement: Both thin-slice T2-WI and SRR effectively improve image quality and diagnostic performance, providing valuable options for optimizing preoperative vascular assessment in PDAC. Non-invasive and accurate assessment of vascular invasion supports treatment planning and avoids futile surgery.
Key points: Vascular invasion evaluation is critical for the surgical eligibility of PDAC. SRR improved image quality and vascular assessment in T2WI. Utilizing thin-slice T2WI and SRR aids in clinical decision making for PDAC.
目的:探讨薄层t2加权成像(T2WI)和超分辨率重建(SRR)在胰腺导管腺癌(PDAC)血管浸润术前评估中的应用价值。方法:回顾性纳入95例术前MRI的pdac作为训练集,不同层厚的非重构T2WI (NRT2) (NRT2-3、3mm;NRT2-5,≥5mm)。仅用NRT2-5收集前瞻性试验集(n = 125)。利用深度学习网络生成不同切片厚度(SRT2-3、3 mm;SRT2-5,≥5mm)。评估图像质量,包括信噪比(SNR)、噪声对比比(CNR)和信号强度比(SIRt/p,肿瘤/胰腺;衬衫/ b、肿瘤/背景)。利用曲线下面积(AUC)评价血管侵犯的诊断效果,并比较重建前后不同切片厚度的血管侵犯诊断效果。结果:与NRT2-5相比,SRT2-5具有更高的信噪比和SIRt/p (74.18 vs 72.46;1.42 vs 1.30;与NRT2-3相比,p 2-3显示SIRt/p和SIRt/b升高(1.35 vs 1.31;2.73 vs 2.58;p 2-5的CNR、SIRt/p和SIRt/b均高于NRT2-3 (p 2-3在评估静脉侵犯方面优于NRT2-5 (AUC: 0.732 vs 0.597, p = 0.021)。SRR改善静脉评估(AUC: NRT2-3, 0.927 vs 0.732;NRT2-5, 0.823 vs 0.597;p 2-5与NRT2-3在静脉评估中的疗效相当(AUC: 0.823 vs 0.732, p = 0.162)。结论:T2WI和SRR可有效提高PDAC静脉侵犯的图像质量和诊断效果。带SRR的厚层T2WI是薄层T2WI的潜在替代方案。关键相关性声明:薄层T2-WI和SRR均有效提高了图像质量和诊断性能,为优化PDAC术前血管评估提供了有价值的选择。无创和准确的血管入侵评估支持治疗计划,避免无效的手术。血管侵犯评估对PDAC的手术资格至关重要。SRR改善了T2WI图像质量和血管评估。薄层T2WI和SRR对PDAC的临床决策有帮助。
期刊介绍:
Insights into Imaging (I³) is a peer-reviewed open access journal published under the brand SpringerOpen. All content published in the journal is freely available online to anyone, anywhere!
I³ continuously updates scientific knowledge and progress in best-practice standards in radiology through the publication of original articles and state-of-the-art reviews and opinions, along with recommendations and statements from the leading radiological societies in Europe.
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A balanced combination of review articles, original papers, short communications from European radiological congresses and information on society matters makes I³ an indispensable source for current information in this field.
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The journal went open access in 2012, which means that all articles published since then are freely available online.