Dynamics and evolution of transposable elements in mosquito genomes

IF 4.8 1区农林科学 Q1 BIOLOGY

Current opinion in insect science Pub Date : 2025-06-28 DOI:10.1016/j.cois.2025.101406

Josquin Daron, Alexander Bergman, Louis Lambrechts

引用次数: 0

Abstract

Decoding mosquito genomes is essential for understanding their role as vectors of human pathogens. Transposable elements (TEs), once considered ‘junk DNA’, are now recognized as key drivers of genomic plasticity and evolution. These mobile DNA fragments are more abundant in culicine than anopheline mosquitoes, influencing their genome size and complexity. TEs may contribute to mosquito adaptation, influencing traits such as insecticide resistance and habitat expansion. Recent advances in long-read sequencing technologies and functional assays are uncovering TE dynamics, but challenges remain in measuring and manipulating their activity, which is critical to demonstrate their phenotypic effects. Further research into the environmental and biological conditions that activate TEs in mosquitoes, as well as the host mechanisms of TE regulation, such as small RNA pathways, will significantly enhance our understanding of mosquito biology.

查看原文本刊更多论文

蚊子基因组转座因子的动态和进化。

破译蚊子基因组对于了解它们作为人类病原体媒介的作用至关重要。转座因子（te），曾经被认为是“垃圾DNA”，现在被认为是基因组可塑性和进化的关键驱动因素。这些可移动的DNA片段在烹饪中比按蚊更丰富，影响了它们的基因组大小和复杂性。TEs可能有助于蚊子适应，影响杀虫剂抗性和栖息地扩展等性状。长读测序技术和功能分析的最新进展揭示了TE动力学，但在测量和操纵其活性方面仍然存在挑战，这对于证明其表型效应至关重要。进一步研究激活蚊子体内TE的环境和生物条件，以及TE调控的宿主机制，如小RNA途径，将大大提高我们对蚊子生物学的认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current opinion in insect science BIOLOGYECOLOGYENTOMOLOGY-ECOLOGY

CiteScore

10.40

自引率

1.90%

发文量

113

期刊介绍： Current Opinion in Insect Science is a new systematic review journal that aims to provide specialists with a unique and educational platform to keep up–to–date with the expanding volume of information published in the field of Insect Science. As this is such a broad discipline, we have determined themed sections each of which is reviewed once a year. The following 11 areas are covered by Current Opinion in Insect Science. -Ecology -Insect genomics -Global Change Biology -Molecular Physiology (Including Immunity) -Pests and Resistance -Parasites, Parasitoids and Biological Control -Behavioural Ecology -Development and Regulation -Social Insects -Neuroscience -Vectors and Medical and Veterinary Entomology There is also a section that changes every year to reflect hot topics in the field. Section Editors, who are major authorities in their area, are appointed by the Editors of the journal. They divide their section into a number of topics, ensuring that the field is comprehensively covered and that all issues of current importance are emphasized. Section Editors commission articles from leading scientists on each topic that they have selected and the commissioned authors write short review articles in which they present recent developments in their subject, emphasizing the aspects that, in their opinion, are most important. In addition, they provide short annotations to the papers that they consider to be most interesting from all those published in their topic over the previous year.