Ranking pre-trained speech embeddings in Parkinson's disease detection: Does Wav2Vec 2.0 outperform its 1.0 version across speech modes and languages?

IF 4.1 2区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Computational and structural biotechnology journal Pub Date : 2025-06-07 eCollection Date: 2025-01-01 DOI:10.1016/j.csbj.2025.06.022
Ondrej Klempir, Adela Skryjova, Ales Tichopad, Radim Krupicka
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Abstract

Speech and language technologies are effective tools for identifying the distinct speech changes associated with Parkinson's disease (PD), enabling earlier and more accurate diagnosis. Models leveraging recent advancements in self-supervised speech pretraining, such as Wav2Vec, have demonstrated superior performance over traditional feature extraction methods. While Wav2Vec 2.0 has been successfully utilized for PD detection, a rigorous quantitative comparison with Wav2Vec 1.0 is needed to comprehensively evaluate its advantages, limitations, and applicability across different speech modes in PD. This study presents a systematic comparison of Wav2Vec 1.0 and Wav2Vec 2.0 embeddings across three multilingual datasets using various classification approaches to classify normal (healthy controls; HC) and PD-affected speech. Additionally, both Wav2Vec 1.0 and 2.0 were benchmarked against traditional baseline features across diverse linguistic contexts, including spontaneous speech, non-spontaneous speech, and isolated vowels. A multicriteria TOPSIS approach was employed to rank feature extraction methods, revealing that Wav2Vec 2.0 excelled across speech modes, with its first transformer layer demonstrating the best performance for classifying read text and monologue, and its feature extractor performing best in vowel-based classification. In contrast, Wav2Vec 1.0, while generally outperformed by Wav2Vec 2.0, still provided a more efficient alternative with competitive performance. Finally, we combined selected layers from both architectures and have demonstrated improved diagnostic accuracy in vowel-based classification. This comparative analysis underscores the strengths of both Wav2Vec architectures and informs their optimal use in PD detection.

在帕金森病检测中对预训练语音嵌入进行排名:Wav2Vec 2.0在语音模式和语言方面是否优于其1.0版本?
语音和语言技术是识别与帕金森病(PD)相关的不同语言变化的有效工具,可以实现更早、更准确的诊断。利用自我监督语音预训练的最新进展的模型,如Wav2Vec,已经证明了比传统特征提取方法更优越的性能。虽然Wav2Vec 2.0已经成功地用于PD检测,但需要与Wav2Vec 1.0进行严格的定量比较,以全面评估其在PD中不同语音模式的优势、局限性和适用性。本研究采用不同的分类方法对三种多语言数据集上的Wav2Vec 1.0和Wav2Vec 2.0嵌入进行了系统比较,以对正常(健康对照;HC)和pd影响言语。此外,Wav2Vec 1.0和2.0在不同的语言背景下,包括自发语音、非自发语音和孤立元音,都以传统的基线特征为基准进行基准测试。采用多标准TOPSIS方法对特征提取方法进行了排名,结果表明,Wav2Vec 2.0在各种语音模式下都表现出色,其中第一个变压器层在分类阅读文本和独白方面表现最佳,其特征提取器在基于元音的分类中表现最佳。相比之下,Wav2Vec 1.0虽然总体上优于Wav2Vec 2.0,但仍然提供了一个更有效的替代方案,具有竞争力的性能。最后,我们结合了两个体系结构中的选择层,并证明了基于元音分类的诊断准确性。这种比较分析强调了两种Wav2Vec架构的优势,并告知它们在PD检测中的最佳使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Computational and structural biotechnology journal
Computational and structural biotechnology journal Biochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
9.30
自引率
3.30%
发文量
540
审稿时长
6 weeks
期刊介绍: Computational and Structural Biotechnology Journal (CSBJ) is an online gold open access journal publishing research articles and reviews after full peer review. All articles are published, without barriers to access, immediately upon acceptance. The journal places a strong emphasis on functional and mechanistic understanding of how molecular components in a biological process work together through the application of computational methods. Structural data may provide such insights, but they are not a pre-requisite for publication in the journal. Specific areas of interest include, but are not limited to: Structure and function of proteins, nucleic acids and other macromolecules Structure and function of multi-component complexes Protein folding, processing and degradation Enzymology Computational and structural studies of plant systems Microbial Informatics Genomics Proteomics Metabolomics Algorithms and Hypothesis in Bioinformatics Mathematical and Theoretical Biology Computational Chemistry and Drug Discovery Microscopy and Molecular Imaging Nanotechnology Systems and Synthetic Biology
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