Venous thromboembolism and worse overall survival in gynaecological cancers: cohort study.

IF 2 4区医学 Q3 HEALTH CARE SCIENCES & SERVICES

BMJ Supportive & Palliative Care Pub Date : 2025-06-30 DOI:10.1136/spcare-2025-005488

Ingrid de Araujo Trugilho, Marcos José Pereira Renni, Giselle Coutinho Medeiros, Luiz Claudio Santos Thuler, Anke Bergmann

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引用次数: 0

Abstract

Purpose: To assess the association of venous thromboembolism (VTE) on the overall survival (OS) of patients with gynaecological cancer (GC) according to tumour topography.

Methods: This study comprises a retrospective cohort of women diagnosed with GC (cervical (CC), uterine (UC), ovarian (OC), vaginal (VgC) and vulvar cancers (VvC)) submitted to Doppler limb ultrasonography or chest pulmonary angiography. OS was assessed considering death as an event, and the follow-up time was censored on the date of the last hospital visit. The Kaplan-Meier method and a Cox multiple regression model were applied, considering p<0.05 as statistically significant. This research was approved by the Research Ethics Committee under No. 2480677.

Results: A total of 1885 women were included in this study. The most frequent cancer topography was CC (56.9%). Over half of the patients (53%) presented advanced disease staging, and 41% presented at least one thromboembolic event, while 74% evolved to death during the study period. The median OS of patients who developed VTE was 20.6 months, and of patients who did not present VTE was 39 months (p<0.001). When stratified by topography, an association with death was observed among patients who developed VTE for all analysed topographies, with an exceeded hazard ranging from 38% to 95%.

Conclusion: Decreased survival times and association with death were observed in patients who developed VTE in CC, UC, OC, VgC and VvC cases.

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妇科癌症的静脉血栓栓塞和更差的总生存率：队列研究。

目的：探讨静脉血栓栓塞（VTE）与妇科癌（GC）患者总生存期（OS）的关系。方法：本研究包括对诊断为胃癌(宫颈癌（CC）、子宫癌（UC）、卵巢癌（OC）、阴道癌（VgC）和外阴癌（VvC）的妇女进行多普勒肢体超声检查或胸肺血管造影。将死亡作为事件评估OS，随访时间在最后一次医院就诊之日审查。采用Kaplan-Meier法和Cox多元回归模型，结果：本研究共纳入1885名女性。最常见的肿瘤地形是CC（56.9%）。超过一半的患者（53%）出现晚期疾病分期，41%出现至少一次血栓栓塞事件，而74%的患者在研究期间死亡。发生静脉血栓栓塞患者的中位生存期为20.6个月，未发生静脉血栓栓塞患者的中位生存期为39个月。结论：在CC、UC、OC、VgC和VvC患者中，发生静脉血栓栓塞患者的生存期缩短并与死亡相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMJ Supportive & Palliative Care Medicine-Medicine (miscellaneous)

CiteScore

4.60

自引率

7.40%

发文量

170

期刊介绍： Published quarterly in print and continuously online, BMJ Supportive & Palliative Care aims to connect many disciplines and specialties throughout the world by providing high quality, clinically relevant research, reviews, comment, information and news of international importance. We hold an inclusive view of supportive and palliative care research and we are able to call on expertise to critique the whole range of methodologies within the subject, including those working in transitional research, clinical trials, epidemiology, behavioural sciences, ethics and health service research. Articles with relevance to clinical practice and clinical service development will be considered for publication. In an international context, many different categories of clinician and healthcare workers do clinical work associated with palliative medicine, specialist or generalist palliative care, supportive care, psychosocial-oncology and end of life care. We wish to engage many specialties, not only those traditionally associated with supportive and palliative care. We hope to extend the readership to doctors, nurses, other healthcare workers and researchers in medical and surgical specialties, including but not limited to cardiology, gastroenterology, geriatrics, neurology, oncology, paediatrics, primary care, psychiatry, psychology, renal medicine, respiratory medicine.