Awareness and intention to use event-driven and long-acting injectable pre-exposure prophylaxis among adolescent and young men who have sex with men and transgender women in Brazil: a cross-sectional study

IF 4.9 1区医学 Q2 IMMUNOLOGY

Journal of the International AIDS Society Pub Date : 2025-07-02 DOI:10.1002/jia2.26479

Laio Magno, Beo Oliveira Leite, Alexandre Grangeiro, Lorenza Dezanet, Fabiane Soares, Inês Dourado

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引用次数: 0

Abstract

Introduction

New pre-exposure prophylaxis (PrEP) options, including event-driven and long-acting injectable, may enhance HIV prevention strategies among adolescents and youth. This study examined awareness and intention to use event-driven and long-acting injectable PrEP, along with associated factors, among adolescent and young men who have sex with men and transgender women.

Methods

A cross-sectional study was conducted between December 2020 and February 2022 among men who have sex with men and young transgender women aged 15–20 years, who participated in a daily oral PrEP cohort study in Salvador and São Paulo, Brazil. Binomial logistic regression models analysed factors associated with the intention to use event-driven and long-acting injectable PrEP.

Results

A total of 1221 participants were enrolled in the cohort at the time of this analysis, with 597 responding to the survey. Awareness of event-driven and long-acting injectable PrEP was reported by 15.3% and 18.0% of participants, respectively. Intention to use event-driven PrEP was reported by 56.4% of participants, while 81.5% expressed intention to use long-acting injectable PrEP. Participants with lower and moderate adherence to daily oral PrEP were more likely to intend to use event-driven PrEP (OR = 1.79; 95% CI: 1.04–3.08), whereas those who reported always or often using condoms in insertive anal sex with steady or casual partners were less likely to intend to use event-driven PrEP (OR = 0.37; 95% CI: 0.15–0.90). For long-acting injectable PrEP, participants with middle (OR = 1.93; 95% CI: 1.05–3.53) or low socio-economic status (OR = 3.13; 95% CI: 1.30–7.51) and those reporting three or more casual partners in the past 3 months (OR = 2.25; 95% CI: 1.30–3.89) were more likely to intend to use long-acting injectable PrEP. Conversely, participants who had never used daily oral PrEP were less likely to intend to use long-acting injectable PrEP (OR = 0.31; 95% CI: 0.11–0.92).

Conclusions

Adolescents and young people in Brazil demonstrated a stronger preference for long-acting injectable over event-driven PrEP, with sexual behaviour patterns significantly influencing choices. Expanding prevention options may enhance PrEP uptake and adherence, improving HIV prevention strategies among adolescents and young adults.

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巴西发生男男性行为的青少年和年轻男性以及跨性别女性使用事件驱动和长效注射暴露前预防的意识和意向：一项横断面研究

新的暴露前预防（PrEP）选择，包括事件驱动和长效注射，可能会加强青少年和青年的艾滋病毒预防战略。本研究调查了与男性发生性关系的青少年和年轻男性以及变性女性使用事件驱动和长效注射PrEP的意识和意图，以及相关因素。方法在2020年12月至2022年2月期间，在巴西萨尔瓦多和圣保罗参加每日口服PrEP队列研究的15-20岁男男性行为者和年轻变性女性中进行横断面研究。二项逻辑回归模型分析了与使用事件驱动和长效注射PrEP相关的因素。结果在本分析时，共有1221名参与者纳入队列，其中597人回应了调查。分别有15.3%和18.0%的参与者报告了事件驱动和长效注射PrEP的意识。56.4%的参与者报告有意使用事件驱动PrEP，而81.5%的参与者表示有意使用长效注射PrEP。每日口服PrEP依从性较低和中等的参与者更有可能打算使用事件驱动PrEP (OR = 1.79；95% CI: 1.04-3.08)，而那些报告在与稳定或随意的伴侣进行插入性肛交时总是或经常使用避孕套的人不太可能打算使用事件驱动的PrEP (or = 0.37；95% ci: 0.15-0.90)。对于长效注射PrEP，中等(OR = 1.93；95% CI: 1.05-3.53)或低社会经济地位(or = 3.13；95% CI: 1.30-7.51)和在过去3个月内报告有3个或更多的临时伴侣的人(or = 2.25；95% CI: 1.30-3.89)更倾向于使用长效注射PrEP。相反，从未使用过每日口服PrEP的参与者不太可能打算使用长效注射PrEP (OR = 0.31；95% ci: 0.11-0.92)。结论：巴西的青少年和年轻人更倾向于长效注射剂，而不是事件驱动的PrEP，性行为模式显著影响选择。扩大预防选择可以提高预防措施的接受和坚持，改善青少年和年轻人的艾滋病毒预防战略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the International AIDS Society IMMUNOLOGY-INFECTIOUS DISEASES

CiteScore

8.60

自引率

10.00%

发文量

186

审稿时长

>12 weeks

期刊介绍： The Journal of the International AIDS Society (JIAS) is a peer-reviewed and Open Access journal for the generation and dissemination of evidence from a wide range of disciplines: basic and biomedical sciences; behavioural sciences; epidemiology; clinical sciences; health economics and health policy; operations research and implementation sciences; and social sciences and humanities. Submission of HIV research carried out in low- and middle-income countries is strongly encouraged.