Neurotoxic risks of long-term environmental exposure to pesticides: a review

IF 5.4 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Chemico-Biological Interactions Pub Date : 2025-06-28 DOI:10.1016/j.cbi.2025.111626

Yumeng Leng , Ye Zeng , Yuning Zhang , Jialin Zhang , Hao Xin , Mingyang Hou , Siman Ma , Hong Zhang

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引用次数: 0

Abstract

Pesticides are chemical substances that prevent pests, control weeds, sterilize, and regulate plant growth. Although mechanized spraying of pesticides significantly improves operational efficiency, excessive use and improper handling of pesticides can lead to environmental pollution, resulting in long-term exposure of nontarget organisms and causing toxicity, particularly neurotoxicity in these organisms. This review summarizes the toxic effects of long-term pesticide exposure on various neurological functions, providing insights for future studies on pesticide exposure. Furthermore, it discusses the role of pesticide exposure in the pathogenesis of neurological and psychiatric disorders and serves as a reference for the prevention, treatment, and management of neurotoxicity resulting from long-term pesticide exposure. The findings are expected to inspire future research aimed at mitigating environmental pollution and enhancing the quality of life for nontarget organisms in the environment.

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长期环境暴露于农药的神经毒性风险：综述

农药是预防害虫、控制杂草、消毒和调节植物生长的化学物质。虽然机械化喷洒农药可以显著提高作业效率，但农药的过量使用和不当处理会导致环境污染，导致非目标生物长期暴露，并对这些生物产生毒性，特别是神经毒性。本文综述了长期农药暴露对多种神经功能的毒性作用，为今后农药暴露研究提供参考。此外，本文还讨论了农药暴露在神经和精神疾病发病机制中的作用，为长期农药暴露引起的神经毒性的预防、治疗和管理提供参考。这一发现有望激发未来旨在减轻环境污染和提高环境中非目标生物生活质量的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemico-Biological Interactions 生物-毒理学

CiteScore

7.70

自引率

3.90%

发文量

410

审稿时长

36 days

期刊介绍： Chemico-Biological Interactions publishes research reports and review articles that examine the molecular, cellular, and/or biochemical basis of toxicologically relevant outcomes. Special emphasis is placed on toxicological mechanisms associated with interactions between chemicals and biological systems. Outcomes may include all traditional endpoints caused by synthetic or naturally occurring chemicals, both in vivo and in vitro. Endpoints of interest include, but are not limited to carcinogenesis, mutagenesis, respiratory toxicology, neurotoxicology, reproductive and developmental toxicology, and immunotoxicology.