Comparison of laboratory results and pain perception in self-sampled capillary blood versus venous blood sampling: a systematic review and meta-analysis

IF 2.1 3区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

Clinical biochemistry Pub Date : 2025-06-27 DOI:10.1016/j.clinbiochem.2025.110965

Dominik Schröder , Angelika Hafke , Eva Hummers , Christopher Schuchardt , Christiane A. Müller , Linda Hoffmeister , Christine Happle , Alexandra Dopfer-Jablonka , Georg M.N. Behrens , Julie Schanz , Frank Müller

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Abstract

Blood sampling is an essential part of medical diagnostics and treatment. Recent advances in capillary blood self-collection (BSC) devices offer promising alternatives to traditional venipuncture. However, the concordance between laboratory results from self-collected capillary samples and the gold standard venous collection requires systematic evaluation before clinical implementation. We conducted a systematic review and meta-analysis comparing laboratory results and pain perception between self-collected capillary and venous blood samples. From 1,436 identified studies, 26 met the inclusion criteria. The overall correlation between capillary BSC and venous samples was strong (r = 0.89, 95 % CI: 0.86–0.92) with high heterogeneity (I² = 94.2 %). For dichotomous outcomes, concordance was excellent (0.99, 95 % CI: 0.98–1.00). Capillary BSC was associated with significantly lower pain scores than venipuncture (SMD = -0.65, 95 % CI = -0.96; −0.35), with upper arm devices having lower pain scores compared to fingerprick methods. Despite methodological heterogeneity, capillary BSC shows strong agreement with venous sampling for most lab parameters and reduces patient discomfort. It appears especially promising for chronic disease monitoring, patients with difficult venous access, and resource-limited settings. Future studies should standardize collection protocols, assess clinical outcomes, and analyze cost-effectiveness. Although no included study showed improved disease management or cost benefits, broader BSC use may enhance healthcare accessibility while maintaining diagnostic accuracy.

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实验室结果和自检毛细管血与静脉血的疼痛感知比较：系统回顾和荟萃分析

血液取样是医学诊断和治疗的重要组成部分。毛细管血液自我采集（BSC）装置的最新进展为传统静脉穿刺提供了有希望的替代方案。然而，自采毛细血管样本的实验室结果与金标准静脉采集结果之间的一致性需要在临床实施前进行系统评估。我们进行了系统回顾和荟萃分析，比较了实验室结果和自行采集的毛细血管和静脉血样本之间的疼痛感知。在1436项确定的研究中，26项符合纳入标准。毛细血管BSC与静脉样本总体相关性强（r = 0.89, 95% CI: 0.86 ~ 0.92），异质性高（I2 = 94.2%）。对于二分类结果，一致性非常好（0.99,95% CI: 0.98-1.00）。毛细血管BSC的疼痛评分明显低于静脉穿刺(SMD = -0.65, 95% CI = -0.96；−0.35)，与针刺法相比，上臂装置的疼痛评分较低。尽管方法上存在异质性，毛细血管BSC在大多数实验室参数上与静脉取样显示出强烈的一致性，并减少了患者的不适。对于慢性疾病监测、静脉通路困难的患者和资源有限的环境，它显得尤其有希望。未来的研究应规范收集方案，评估临床结果，并分析成本效益。虽然没有纳入的研究显示改善疾病管理或成本效益，但广泛使用平衡记分卡可以在保持诊断准确性的同时提高医疗保健可及性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical biochemistry 医学-医学实验技术

CiteScore

5.10

自引率

0.00%

发文量

151

审稿时长

25 days

期刊介绍： Clinical Biochemistry publishes articles relating to clinical chemistry, molecular biology and genetics, therapeutic drug monitoring and toxicology, laboratory immunology and laboratory medicine in general, with the focus on analytical and clinical investigation of laboratory tests in humans used for diagnosis, prognosis, treatment and therapy, and monitoring of disease.