Ensembles of cationic conjugated polymer and anionic platinum(ii) complexes: from FRET properties to application studies in E. coli imaging and singlet oxygen generation†

IF 7.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Chemical Science Pub Date : 2025-07-01 DOI:10.1039/D5SC01244A

Angela Lok-Yin So, Jungu Guo, Huanxiang Yuan, Qi Shen, Eric Ka-Ho Wong, Shu Wang and Vivian Wing-Wah Yam

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引用次数: 0

Abstract

A series of anionic alkynylplatinum(II) complexes with terpyridine (tpy) or 2,6-bis(benzimidazol-2′-yl)pyridine (bzimpy) as the tridentate N-donor pincer ligand has been synthesized and characterized. These complexes are found to form ensembles with a cationic poly(fluorene-co-phenylene) derivative (PFP-NMe₃⁺) through electrostatic, Pt(II)⋯Pt(II) and π–π stacking interactions. Förster resonance energy transfer (FRET) has been found to take place, consequently gave rise to fluorescence quenching of the polymer donor and the emergence of low-energy emission from the platinum(II) complex assemblies. The spectroscopic and FRET properties of the two-component systems have been investigated by UV-vis absorption, emission and Stern–Volmer quenching studies. Pathogen imaging and photodynamic therapy (PDT) studies using the polymer–platinum(II) complex ensembles have demonstrated better performance compared to that using PFP-NMe₃⁺ only, which highlights the potential of this class of ensembles for various biological applications.

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阳离子共轭聚合物和阴离子铂（II）配合物的集合：从FRET性质到大肠杆菌成像和单线态氧生成的应用研究

合成了一系列以三吡啶（tpy）或2,6-二（苯并咪唑-2′-酰基）吡啶（bzimpy）为三齿n给体螯合体的阴离子炔基铂（II）配合物，并对其进行了表征。发现这些配合物通过静电、Pt(II)⋯Pt（II）和π -π堆叠相互作用与阳离子聚芴-共苯衍生物（PFP-NMe3+）形成系综。Förster共振能量转移（FRET）已被发现发生，从而引起聚合物供体的荧光猝灭和铂（II）配合物组装体的低能发射的出现。通过紫外-可见吸收、发射和斯特恩-沃尔默猝灭研究了双组分体系的光谱和FRET特性。与仅使用PFP-NMe3+相比，使用聚合物-铂（II）复合物体系的病原体成像和光动力治疗（PDT）研究显示出更好的性能，这凸显了这类体系在各种生物学应用中的潜力。

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来源期刊

Chemical Science CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

14.40

自引率

4.80%

发文量

1352

审稿时长

2.1 months

期刊介绍： Chemical Science is a journal that encompasses various disciplines within the chemical sciences. Its scope includes publishing ground-breaking research with significant implications for its respective field, as well as appealing to a wider audience in related areas. To be considered for publication, articles must showcase innovative and original advances in their field of study and be presented in a manner that is understandable to scientists from diverse backgrounds. However, the journal generally does not publish highly specialized research.