The Effectiveness and Safety of Three Treatment Regimens of Topical Minoxidil 5.0%, Betamethasone 0.064% w/w, and Castor and Jojoba Oils for Alopecia Areata: A Multicenter Cohort Study

IF 3.7 4区医学 Q1 DERMATOLOGY

Dermatologic Therapy Pub Date : 2025-07-01 DOI:10.1155/dth/6631359

Amir Abadi, Wala Abdeljawad, Emad Khatib, Shorok Jaber, Sari Taha, Munther Ardah, Manal Ardah, Basma Damiri

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引用次数: 0

Abstract

Introduction: Alopecia areata (AA) is a chronic, remitting–relapsing dermatological disease that is associated with a substantial psychological impact. Despite the availability of a wide range of therapeutic options, none provides a cure for AA. This study aimed to compare the effectiveness of topical betamethasone as a monotherapy with combinations of topical betamethasone with either topical minoxidil 5% or a herbal preparation of castor and jojoba oils.

Methods: This was a multicenter, cohort study in which patients diagnosed with AA were taking one of three treatment regimens: a reference monotherapy of topical betamethasone 0.064% w/w; combined topical minoxidil and betamethasone 0.064% w/w; or combined topical betamethasone 0.064% w/w and a herbal preparation of castor and jojoba oils. The data were collected at the beginning of the study using a questionnaire. Patients were assessed at three follow-up visits for hair regrowth using trichoscopy as the primary outcome. Patient satisfaction and compliance were assessed using 10-point scales.

Results: The final sample consisted of 278 patients. Combined topical minoxidil–betamethasone therapy was significantly associated with higher rates of hair regrowth (p = 0.006), patient satisfaction (p < 0.001), and shorter median time to first improvement (p < 0.001). Combined minoxidil/betamethasone was more likely to achieve hair regrowth than the other two treatments at the multivariate level (aRR = 2.239, CI = 1.153–4.347). Moreover, hair regrowth was significantly different between the treatment groups after each phase, with hair regrowth at the final phase observed in 83.2% of patients using combined topical minoxidil and betamethasone.

Conclusions: The use of topical minoxidil–betamethasone combination for AA was superior to betamethasone monotherapy or combined with herbal preparations. Randomized clinical trials are needed to strengthen the evidence.

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查看原文本刊更多论文

外用米诺地尔5.0%、倍他米松0.064% w/w、蓖麻和荷荷巴油治疗斑秃的有效性和安全性：一项多中心队列研究

简介：斑秃（AA）是一种慢性、反复发作的皮肤病，与严重的心理影响有关。尽管有各种各样的治疗方法可供选择，但没有一种能治愈嗜酒成瘾。本研究旨在比较局部倍他米松作为单一疗法与局部倍他米松与局部米诺地尔5%或蓖麻和荷荷巴油的草药制剂联合使用的有效性。方法：这是一项多中心队列研究，诊断为AA的患者接受三种治疗方案中的一种：局部倍他米松0.064% w/w的参考单药治疗；米诺地尔联合倍他米松外用0.064% w/w；或结合局部倍他米松0.064% w/w和蓖麻和荷荷巴油的草药制剂。数据是在研究开始时通过问卷调查收集的。患者在三次随访中评估毛发再生情况，使用毛发镜检查作为主要结果。采用10分制评估患者满意度和依从性。结果：最终样本包括278例患者。局部米诺地尔-倍他米松联合治疗与较高的毛发再生率（p = 0.006）、患者满意度(p <；0.001)，首次改善的中位时间更短(p <；0.001)。在多因素水平上，米诺地尔/倍他米松联合治疗比其他两种治疗更容易实现头发再生（aRR = 2.239, CI = 1.153 ~ 4.347）。此外，治疗组在每个阶段后的毛发再生也有显著差异，使用局部米诺地尔和倍他米松联合治疗的患者在最后阶段的毛发再生率为83.2%。结论：米诺地尔-倍他米松联合外用治疗AA优于倍他米松单药治疗或与中药制剂联合治疗。需要随机临床试验来加强证据。

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来源期刊

Dermatologic Therapy 医学-皮肤病学

CiteScore

7.00

自引率

8.30%

发文量

711

审稿时长

3 months

期刊介绍： Dermatologic Therapy has been created to fill an important void in the dermatologic literature: the lack of a readily available source of up-to-date information on the treatment of specific cutaneous diseases and the practical application of specific treatment modalities. Each issue of the journal consists of a series of scholarly review articles written by leaders in dermatology in which they describe, in very specific terms, how they treat particular cutaneous diseases and how they use specific therapeutic agents. The information contained in each issue is so practical and detailed that the reader should be able to directly apply various treatment approaches to daily clinical situations. Because of the specific and practical nature of this publication, Dermatologic Therapy not only serves as a readily available resource for the day-to-day treatment of patients, but also as an evolving therapeutic textbook for the treatment of dermatologic diseases.