Single-Molecule Graphene Quantum Dot: a Novel Efficient Photosensitizer for Photodynamic Cancer Therapy

IF 7.6 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Jintao Chen, Shiru Yin, futing Yang, Shengnan Guo, Jiaojiao Zhang, Zhenming Lu, Tian Gao
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引用次数: 0

Abstract

Graphene quantum dots (GQDs) can efficiently generate reactive oxygen species (ROS) under light irradiation, demonstrating significant potential for photodynamic therapy (PDT) applications. However, GQDs are often multicomponent mixtures with highly complex structures, which significantly hinders their clinical applications. Therefore, it is urgent to design and synthesize well-defined GQDs with excellent PDT performance. In this work, a novel single-molecule hydrophilic pure graphene quantum dot (HPGQD), containing 132 sp² conjugated carbon atoms, was prepared through an organic synthetic route using single-benzene-ring molecules as precursors. The HPGQD features a unique D-12A structure, comprising one large electron donor center and 12 electron acceptors, which grants it exceptional ROS release capabilities with a singlet oxygen (1O2) quantum yield of 0.85. Notably, under light irradiation, HPGQD can rapidly generate abundant ROS within 30 s and scavenge them after 10 min, which holds promise for eliminating the need for prolonged light avoidance in patients undergoing PDT. It has been successfully applied to both in vitro (IC50: 0.22 μmol L-1) and in vivo (tumor weight inhibition rate: 71%) PDT for cancer treatment. The innovative design, synthesis, and PDT application of single-molecule HPGQD pave towards accelerated clinical applications of carbon nanomaterials, advancing the frontier of nanotherapeutic research.
单分子石墨烯量子点:一种用于光动力癌症治疗的新型高效光敏剂
石墨烯量子点(GQDs)可以在光照射下有效地产生活性氧(ROS),在光动力治疗(PDT)中具有重要的应用潜力。然而,GQDs通常是结构高度复杂的多组分混合物,这极大地阻碍了其临床应用。因此,迫切需要设计和合成具有良好PDT性能且定义良好的GQDs。本文以单苯环分子为前体,通过有机合成的方法制备了一种新型的单分子亲水纯石墨烯量子点(HPGQD),该量子点含有132个sp²共轭碳原子。HPGQD具有独特的D-12A结构,包括一个大的电子给体中心和12个电子受体,这使其具有出色的ROS释放能力,单线态氧(10o2)量子产率为0.85。值得注意的是,在光照射下,HPGQD可以在30秒内快速产生大量的ROS,并在10分钟后清除它们,这有望消除PDT患者长时间避光的需要。已成功应用于体外(IC50: 0.22 μmol L-1)和体内(肿瘤重量抑制率:71%)PDT治疗肿瘤。单分子HPGQD的创新设计、合成和PDT应用为加速碳纳米材料的临床应用铺平了道路,推动了纳米治疗研究的前沿。
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来源期刊
Chemical Science
Chemical Science CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
14.40
自引率
4.80%
发文量
1352
审稿时长
2.1 months
期刊介绍: Chemical Science is a journal that encompasses various disciplines within the chemical sciences. Its scope includes publishing ground-breaking research with significant implications for its respective field, as well as appealing to a wider audience in related areas. To be considered for publication, articles must showcase innovative and original advances in their field of study and be presented in a manner that is understandable to scientists from diverse backgrounds. However, the journal generally does not publish highly specialized research.
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