Regulatory mechanism of the SenX3-RegX3 two-component system in Mycobacterium smegmatis: Roles of PhoU in sensing inorganic phosphate levels

IF 4 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Biological Chemistry Pub Date : 2025-06-28 DOI:10.1016/j.jbc.2025.110435

Youjin Seung, Ha-Eun Baik, Eun-Jin Park, Jeong-Il Oh

引用次数: 0

Abstract

The SenX3-RegX3 two-component system (TCS) in mycobacteria, consisting of the SenX3 histidine kinase and the RegX3 response regulator, regulates gene expression related to inorganic phosphate (Pi) acquisition in response to environmental Pi availability.

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耻垢分枝杆菌SenX3-RegX3双组分系统的调控机制：PhoU在感知无机磷酸盐水平中的作用

分枝杆菌SenX3-RegX3双组分系统（TCS）由SenX3组氨酸激酶和RegX3反应调节因子组成，在环境磷素可用性下调控与无机磷酸盐（Pi）获取相关的基因表达。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biological Chemistry Biochemistry, Genetics and Molecular Biology-Biochemistry

自引率

4.20%

发文量

1233

期刊介绍： The Journal of Biological Chemistry welcomes high-quality science that seeks to elucidate the molecular and cellular basis of biological processes. Papers published in JBC can therefore fall under the umbrellas of not only biological chemistry, chemical biology, or biochemistry, but also allied disciplines such as biophysics, systems biology, RNA biology, immunology, microbiology, neurobiology, epigenetics, computational biology, ’omics, and many more. The outcome of our focus on papers that contribute novel and important mechanistic insights, rather than on a particular topic area, is that JBC is truly a melting pot for scientists across disciplines. In addition, JBC welcomes papers that describe methods that will help scientists push their biochemical inquiries forward and resources that will be of use to the research community.