Comparative effects of 10-Hz rTMS and iTBS on cortico-striatal connectivity in major depressive disorder: a sham-controlled study

IF 9.6 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Cheng-Ta Li, Wan-Chen Chang, Chih-Ming Cheng, Tung-Ping Su, Ya-Mei Bai, Pei-Chi Tu
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引用次数: 0

Abstract

Abnormalities in the prefrontal cortex (PFC)-related network play an important role in the pathophysiology of major depressive disorder (MDD). Accumulating evidence indicated that fronto-striatal dysconnectivity is critical to MDD pathogenesis. Whether non-invasive brain stimulation, including 10-Hz repetitive transcranial magnetic stimulation (rTMS) and intermittent theta-burst stimulation (iTBS), may change cortico-striatal functional connectivity (FC) in MDD patients is unclear. Whether the change of cortico-striatal FC is associated with the antidepressant effects is also unknown. In total, 68 adult MDD subjects were randomly assigned to one of three groups: iTBS, 10-Hz rTMS, or sham group. Functional connectivity was analyzed using MRI and seed-based methods. Seeds included left and right dorsal caudate (DC), dorsal rostral putamen (DRP), and ventral rostral putamen (VRP). The results revealed that significant group-by-time interactions in FC were found in all the striatal seeds. Post-hoc analyses revealed significant increases in FC of the left DRP and VRP for both iTBS and rTMS treatments, particularly with the right frontal pole. Greater FC changes of the fronto-striatal networks correlated with the antidepressant effects. The effects of rTMS and iTBS on FCs of the intra-striatal network, default mode network, and other cortico-striatal networks were distinct. In conclusion, the first study demonstrated that iTBS and rTMS had common but unique effects on the cortico-striatal and intra-striatal networks. These results suggest that both treatments regulate brain reward systems and might be used to treat various striatum-related neuropsychiatric illnesses.

10赫兹rTMS和iTBS对重度抑郁症皮质纹状体连通性的比较作用:一项假对照研究
前额叶皮层(PFC)相关网络异常在重度抑郁症(MDD)的病理生理中起重要作用。越来越多的证据表明,额纹状体连接障碍是MDD发病的关键。非侵入性脑刺激,包括10hz重复经颅磁刺激(rTMS)和间歇性脑波爆发刺激(iTBS),是否会改变MDD患者的皮质纹状体功能连通性(FC)尚不清楚。皮质纹状体FC的改变是否与抗抑郁作用有关尚不清楚。总共有68名成年重度抑郁症受试者被随机分为三组:iTBS、10hz rTMS或假手术组。使用MRI和基于种子的方法分析功能连接。种子包括左、右尾状背核(DC)、背吻侧壳核(DRP)和腹吻侧壳核(VRP)。结果表明,在所有纹状体种子中,FC均存在显著的群-时间相互作用。事后分析显示,在iTBS和rTMS治疗中,左侧DRP和VRP的FC显著增加,尤其是右额极。额纹状体网络更大的FC变化与抗抑郁作用相关。rTMS和iTBS对纹状体内网络、默认模式网络和其他皮质纹状体网络的FCs的影响是不同的。综上所述,第一项研究表明iTBS和rTMS对皮质纹状体和纹状体内网络有共同但独特的影响。这些结果表明,这两种治疗方法都能调节大脑奖励系统,并可能用于治疗各种纹状体相关的神经精神疾病。
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来源期刊
Molecular Psychiatry
Molecular Psychiatry 医学-精神病学
CiteScore
20.50
自引率
4.50%
发文量
459
审稿时长
4-8 weeks
期刊介绍: Molecular Psychiatry focuses on publishing research that aims to uncover the biological mechanisms behind psychiatric disorders and their treatment. The journal emphasizes studies that bridge pre-clinical and clinical research, covering cellular, molecular, integrative, clinical, imaging, and psychopharmacology levels.
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