Patients With Crohn's Disease and Terminal Ileum Resection are at Increased Risk of Colorectal Cancer: A Population-Based Study.

IF 4.3 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Inflammatory Bowel Diseases Pub Date : 2025-06-18 DOI:10.1093/ibd/izaf118

Inas Mikhail, Omar Al Ta'ani, Razan Aburumman, Saqr Alsakarneh, Francis A Farraye, Jana G Hashash

引用次数: 0

Abstract

Patients with Crohn's disease (CD) who undergo terminal ileum (TI) resection experience altered bile acid absorption, which may influence colorectal cancer (CRC) risk. We conducted a propensity-matched cohort study using TriNetX to compare CRC risk in patients with CD who underwent TI resection versus those who did not. Terminal ileum resection was associated with an increased risk of CRC (aHR = 2.58, 95% CI, 1.72-3.86). Patients with TI resection also had higher odds of colorectal polyps. These findings suggest the need for heightened CRC surveillance in patients with CD undergoing TI resection.

查看原文本刊更多论文

一项基于人群的研究表明，克罗恩病患者和回肠末端切除术的结直肠癌风险增加。

克罗恩病（CD）患者接受回肠末端（TI）切除术后胆汁酸吸收发生改变，这可能影响结直肠癌（CRC）的风险。我们使用TriNetX进行了一项倾向匹配队列研究，比较行TI切除术和未行TI切除术的CD患者的CRC风险。回肠末端切除术与CRC风险增加相关（aHR = 2.58, 95% CI, 1.72-3.86）。TI切除术的患者发生结肠息肉的几率也更高。这些发现提示，在行TI切除术的CD患者中，需要加强对结直肠癌的监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Inflammatory Bowel Diseases 医学-胃肠肝病学

CiteScore

9.70

自引率

6.10%

发文量

462

审稿时长

1 months

期刊介绍： Inflammatory Bowel Diseases® supports the mission of the Crohn''s & Colitis Foundation by bringing the most impactful and cutting edge clinical topics and research findings related to inflammatory bowel diseases to clinicians and researchers working in IBD and related fields. The Journal is committed to publishing on innovative topics that influence the future of clinical care, treatment, and research.