The significance of protein N-glycosylation in the pathogenesis of lung cancer and its clinical implications

IF 9.1 1区医学 Q1 ONCOLOGY

Cancer letters Pub Date : 2025-06-25 DOI:10.1016/j.canlet.2025.217849

Yibo Huang , Jin Song , Jinfeng Chen , Feng Li , Yi Zhang , Jing-Hua Yang

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Abstract

This comprehensive review systematically elucidates the multifaceted roles of protein N-glycosylation in lung cancer pathogenesis, including its contributions to accelerated cell proliferation, enhanced metastatic potential, promotion of epithelial‒mesenchymal transition (EMT), maintenance of stem cell characteristics, facilitation of immune evasion, preservation of angiogenesis, and diminished drug sensitivity. Additionally, the potential clinical utility of aberrant N-glycosylation is examined as a novel biomarker for early diagnosis, prognostic evaluation, and treatment monitoring in lung cancer. The analysis highlights the critical involvement of N-glycosylation in chemotherapy resistance, targeted therapy, and immunotherapy, offering new perspectives for the development of innovative therapeutic strategies. Furthermore, this review highlights promising applications of antibody-enzyme engineering technology in achieving more precise lung cancer treatments, introducing new opportunities for the field. These findings provide a significant theoretical basis and experimental evidence to support progress in lung cancer research and treatment advancements.

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蛋白n -糖基化在肺癌发病中的意义及其临床意义。

这篇综述系统地阐述了蛋白n -糖基化在肺癌发病机制中的多方面作用，包括加速细胞增殖、增强转移潜能、促进上皮-间质转化（EMT）、维持干细胞特性、促进免疫逃避、保存血管生成和降低药物敏感性。此外，研究人员还研究了异常n -糖基化作为肺癌早期诊断、预后评估和治疗监测的新型生物标志物的潜在临床应用。该分析强调了n -糖基化在化疗耐药、靶向治疗和免疫治疗中的关键作用，为创新治疗策略的发展提供了新的视角。此外，本文重点介绍了抗体酶工程技术在实现更精确的肺癌治疗方面的应用前景，为该领域带来了新的机遇。这些发现为支持肺癌研究和治疗进步提供了重要的理论基础和实验证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer letters 医学-肿瘤学

CiteScore

17.70

自引率

2.10%

发文量

427

审稿时长

15 days

期刊介绍： Cancer Letters is a reputable international journal that serves as a platform for significant and original contributions in cancer research. The journal welcomes both full-length articles and Mini Reviews in the wide-ranging field of basic and translational oncology. Furthermore, it frequently presents Special Issues that shed light on current and topical areas in cancer research. Cancer Letters is highly interested in various fundamental aspects that can cater to a diverse readership. These areas include the molecular genetics and cell biology of cancer, radiation biology, molecular pathology, hormones and cancer, viral oncology, metastasis, and chemoprevention. The journal actively focuses on experimental therapeutics, particularly the advancement of targeted therapies for personalized cancer medicine, such as metronomic chemotherapy. By publishing groundbreaking research and promoting advancements in cancer treatments, Cancer Letters aims to actively contribute to the fight against cancer and the improvement of patient outcomes.