Bioactive properties for borate and borosilicate glass: An in vitro study

Q1 Physics and Astronomy

Journal of Non-Crystalline Solids: X Pub Date : 2025-06-25 DOI:10.1016/j.nocx.2025.100222

Mariam Aljaman , M.H.A. Mhareb , Abdelkrim Mekki , Essam Kotb , N. Alonizan , M.Y. Alqahtani , Hana Almarri , Irshad Baig

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Abstract

In this study, borate-based and borosilicate glass samples according to the composition of xSiO₂-(40-x)B₂O₃-20SrO-20Na₂O-20CaO where x = 0, 10, and 20 mol% were fabricated, and their in vitro bioactivities were evaluated. Morphological and structural studies of the proposed samples before and after immersion in simulated body fluid (SBF) were performed using physiochemical instruments. The XRD results showed that a crystalline phase was formed after the immersion of the glass samples, confirming the bioactivity of these samples. The SEM results revealed changes in the glass morphology after immersion in the crystalline form. The weight-loss results showed that B40Si0 was superior to B20Si20 and B30Si10. The glass samples showed antibacterial activity against four pathogenic bacterial strains, including two Gram-positive and two Gram-negative bacteria. Finally, based on the bioactivity results, it can be concluded that the new bioactive glass is valid for use as a biomaterial for bone and dental healing.

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硼酸盐和硼硅酸盐玻璃的生物活性特性：体外研究

本研究制备了xSiO2-(40-x)B2O3-20SrO-20Na2O-20CaO （x = 0、10和20 mol%）组成的硼酸盐基和硼硅酸盐玻璃样品，并对其体外生物活性进行了评价。利用理化仪器对所建议的样品浸泡在模拟体液（SBF）中前后的形态学和结构进行了研究。XRD结果表明，玻璃样品浸泡后形成结晶相，证实了这些样品的生物活性。扫描电镜结果显示，浸泡在晶体形式后，玻璃形态发生了变化。减重结果表明，B40Si0优于B20Si20和B30Si10。玻璃样品对4种病原菌，包括2种革兰氏阳性菌和2种革兰氏阴性菌均有抗菌活性。最后，根据生物活性的结果，可以得出结论，新的生物活性玻璃是有效的用于骨和牙愈合的生物材料。

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