[Determination of Acetate Content in Hemodialysis Solutions and Dialysis Concentrates by HPLC].

Q4 Medicine

中国医疗器械杂志 Pub Date : 2025-05-30 DOI:10.12455/j.issn.1671-7104.240718

Huadong Wang, Yue Wang, Dong Liu, Xianghui Liu

引用次数: 0

Abstract

This study establishes a high-performance liquid chromatography (HPLC) method for the determination of acetate content in hemodialysis solutions and dialysis concentrates. In this study, Synergi Polar-RP column is utilized. Phosphate buffered saline (50 mmol/L, pH=2.5) is used as a mobile phase. The flow rate is 1.0 mL/min. The wavelength of detection is 212 nm. Results show that the linear relationship of acetate is good in the range of 0.1~20 mmol/L, r =0.999 9 and the spike recoveries are from 98.9%~99.5%, RSD<0.5% ( n=3). This method can easily and accurately determine the acetate content in hemodialysis solutions and dialysis concentrates, and can be applied to quality control in the production and use of such products.

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[HPLC法测定血液透析液和透析浓缩液中醋酸盐含量]。

建立了高效液相色谱法测定血液透析液和透析浓缩液中乙酸盐含量的方法。本研究采用了Synergi Polar-RP色谱柱。磷酸盐缓冲盐水（50 mmol/L, pH=2.5）作为流动相。流速1.0 mL/min。检测波长为212 nm。结果表明：乙酸在0.1~20 mmol/L范围内呈良好的线性关系，r =0.999 9；加样回收率为98.9%~99.5%,RSDn=3；该方法可方便、准确地测定血液透析液和透析浓缩液中醋酸盐的含量，可用于此类产品的生产和使用中的质量控制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中国医疗器械杂志 Medicine-Medicine (all)

CiteScore

0.40

自引率

0.00%

发文量

8086

期刊介绍： Chinese Journal of Medical Instrumentation mainly reports on the development, progress, research and development, production, clinical application, management, and maintenance of medical devices and biomedical engineering. Its aim is to promote the exchange of information on medical devices and biomedical engineering in China and turn the journal into a high-quality academic journal that leads academic directions and advocates academic debates.