Metabolic Reprogramming in Melanoma: An Epigenetic Point of View.

IF 4.3 3区医学 Q2 CHEMISTRY, MEDICINAL

Pharmaceuticals Pub Date : 2025-06-06 DOI:10.3390/ph18060853

Stefano Giuliani, Celeste Accetta, Simona di Martino, Claudia De Vitis, Elena Messina, Edoardo Pescarmona, Maurizio Fanciulli, Gennaro Ciliberto, Rita Mancini, Italia Falcone

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引用次数: 0

Abstract

Metabolic reprogramming and epigenetic alterations are fundamental hallmarks of cancer cells, contributing to adaptation, progression, and resistance. In melanoma, high metabolic-epigenetic plasticity enables the rapid modulation of cell states in response to environmental and therapeutic pressures. Recent studies have highlighted a bidirectional crosstalk between cellular metabolism and epigenetic regulation. Epigenetic modifications influence the transcriptional control of metabolic genes, thereby shaping metabolic phenotypes. Conversely, specific metabolites are essential cofactors or substrates for epigenetic enzymes, directly modulating the epigenome. Understanding the intricate mechanisms of this interaction offers opportunities for the development of innovative tumor management that combines epigenetic, metabolic, and therapy interventions. In this review, we summarize the latest evidence on the role of the metabolism-epigenetics axis in melanoma and discuss its potential clinical implications, aiming to provide a comprehensive overview of metabolic/epigenetic interconnections.

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黑色素瘤的代谢重编程：一个表观遗传学的观点。

代谢重编程和表观遗传改变是癌细胞的基本特征，有助于适应、进展和抵抗。在黑色素瘤中，高代谢-表观遗传可塑性使细胞状态能够快速调节以响应环境和治疗压力。最近的研究强调了细胞代谢和表观遗传调控之间的双向串扰。表观遗传修饰影响代谢基因的转录控制，从而形成代谢表型。相反，特定代谢物是表观遗传酶必不可少的辅助因子或底物，直接调节表观基因组。了解这种相互作用的复杂机制为结合表观遗传、代谢和治疗干预的创新肿瘤管理的发展提供了机会。在这篇综述中，我们总结了代谢-表观遗传轴在黑色素瘤中作用的最新证据，并讨论了其潜在的临床意义，旨在提供代谢/表观遗传相互关系的全面概述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmaceuticals Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

6.10

自引率

4.30%

发文量

1332

审稿时长

6 weeks

期刊介绍： Pharmaceuticals (ISSN 1424-8247) is an international scientific journal of medicinal chemistry and related drug sciences.Our aim is to publish updated reviews as well as research articles with comprehensive theoretical and experimental details. Short communications are also accepted; therefore, there is no restriction on the maximum length of the papers.