Quality of life and functional status of patients referred for transcatheter edge-to-edge repair of severe tricuspid regurgitation: A single-center prospective observational study.
Adam Piasecki, Adam Rdzanek, Ewa Pędzich, Ewa Ostrowska, Paweł Pawłowicz, Angelika Bursa, Agnieszka Kapłon-Cieślicka, Marcin Grabowski, Piotr Scisło, Mariusz Tomaniak
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引用次数: 0
Abstract
Background: Recent years brought a significant increase in the accessibility of interventional treatment of tricuspid regurgitation (TR). However, the characteristics of patients referred for evaluation and factors associated with functional capacity and quality of life (QoL) remain poorly defined.
Aims: To characterize patients undergoing qualification for interventional TR treatment with the focus on parameters associated with QoL and exercise capacity and to assess short-term effects of tricuspid transcatheter edge-to-edge repair (T-TEER).
Material and methods: This is a single-center prospective observational study enrolling consecutive patients with at least severe TR that undergo qualification for interventional TR treatment. Baseline data is collected during index hospitalization and follow-up data during outpatient visits at 30 days post procedure.
Results: We included a total number of 147 patients. Qualification process resulted in 77 (52.4%) qualified for T-TEER. Patients presented with severe heart failure symptoms and high comorbidity burden. The mean baseline Kansas City Cardiomyopathy Questionnaire score was 42.4 (26.1) and New York Heart Association functional class had strongest predictive value. The median baseline 6-minute walk distance (6MWD) was 195.0 (100.0-285.0) meters. The main factors associated with 6MWD were age and low tricuspid annular plane systolic excursion/systolic pulmonary artery pressure. T-TEER reduced TR to moderate or less in 51 of 67 patients and was associated with significant improvement in Kansas City Cardiomyopathy Questionnaire and 6MWD.
Conclusions: Patients with severe TR present with high comorbidity burden, severe HF symptoms and report low QoL. Higher age and low tricuspid annular plane systolic excursion/systolic pulmonary artery pressure are associated with worse 6MWD. Treatment with T-TEER is associated with a significant improvement of QoL and 6MWD at short-term follow-up.
期刊介绍:
Kardiologia Polska (Kardiol Pol, Polish Heart Journal) is the official peer-reviewed journal of the Polish Cardiac Society (PTK, Polskie Towarzystwo Kardiologiczne) published monthly since 1957. It aims to provide a platform for sharing knowledge in cardiology, from basic science to translational and clinical research on cardiovascular diseases.