Quality of life and functional status of patients referred for transcatheter edge-to-edge repair of severe tricuspid regurgitation: A single-center prospective observational study.

IF 3.7 3区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Adam Piasecki, Adam Rdzanek, Ewa Pędzich, Ewa Ostrowska, Paweł Pawłowicz, Angelika Bursa, Agnieszka Kapłon-Cieślicka, Marcin Grabowski, Piotr Scisło, Mariusz Tomaniak
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引用次数: 0

Abstract

Background: Recent years brought a significant increase in the accessibility of interventional treatment of tricuspid regurgitation (TR). However, the characteristics of patients referred for evaluation and factors associated with functional capacity and quality of life (QoL) remain poorly defined.

Aims: To characterize patients undergoing qualification for interventional TR treatment with the focus on parameters associated with QoL and exercise capacity and to assess short-term effects of tricuspid transcatheter edge-to-edge repair (T-TEER).

Material and methods: This is a single-center prospective observational study enrolling consecutive patients with at least severe TR that undergo qualification for interventional TR treatment. Baseline data is collected during index hospitalization and follow-up data during outpatient visits at 30 days post procedure.

Results: We included a total number of 147 patients. Qualification process resulted in 77 (52.4%) qualified for T-TEER. Patients presented with severe heart failure symptoms and high comorbidity burden. The mean baseline Kansas City Cardiomyopathy Questionnaire score was 42.4 (26.1) and New York Heart Association functional class had strongest predictive value. The median baseline 6-minute walk distance (6MWD) was 195.0 (100.0-285.0) meters. The main factors associated with 6MWD were age and low tricuspid annular plane systolic excursion/systolic pulmonary artery pressure. T-TEER reduced TR to moderate or less in 51 of 67 patients and was associated with significant improvement in Kansas City Cardiomyopathy Questionnaire and 6MWD.

Conclusions: Patients with severe TR present with high comorbidity burden, severe HF symptoms and report low QoL. Higher age and low tricuspid annular plane systolic excursion/systolic pulmonary artery pressure are associated with worse 6MWD. Treatment with T-TEER is associated with a significant improvement of QoL and 6MWD at short-term follow-up.

经导管边缘对边缘修复严重三尖瓣反流患者的生活质量和功能状态:一项单中心前瞻性观察研究
背景:近年来,三尖瓣反流(TR)介入治疗的可及性显著增加。然而,用于评估的患者特征以及与功能能力和生活质量(QoL)相关的因素仍然定义不清。目的:通过关注与生活质量和运动能力相关的参数,对接受介入TR治疗资格的患者进行特征描述,并评估三尖瓣经导管边缘到边缘修复(T-TEER)的短期效果。材料和方法:这是一项单中心前瞻性观察性研究,纳入至少有严重TR且符合TR介入治疗资格的连续患者。在指数住院期间收集基线数据,并在手术后30天门诊期间收集随访数据。结果:我们共纳入147例患者。鉴定结果为77例(52.4%)T-TEER合格。患者表现出严重的心衰症状和高的合并症负担。平均基线堪萨斯城心肌病问卷得分为42.4(26.1),纽约心脏协会功能分级具有最强的预测价值。基线6分钟步行距离(6MWD)中位数为195.0(100.0-285.0)米。与6MWD相关的主要因素是年龄和低三尖瓣环平面收缩偏移/收缩期肺动脉压。在67名患者中,51名患者的T-TEER将TR降低至中等或更低,并与堪萨斯城心肌病问卷和6MWD的显着改善相关。结论:严重TR患者合并症负担高,HF症状严重,生活质量低。年龄越大、三尖瓣环平面收缩偏移/收缩期肺动脉压越低,6MWD越严重。在短期随访中,T-TEER治疗与QoL和6MWD的显著改善相关。
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来源期刊
Kardiologia polska
Kardiologia polska 医学-心血管系统
CiteScore
3.00
自引率
24.20%
发文量
431
审稿时长
3-6 weeks
期刊介绍: Kardiologia Polska (Kardiol Pol, Polish Heart Journal) is the official peer-reviewed journal of the Polish Cardiac Society (PTK, Polskie Towarzystwo Kardiologiczne) published monthly since 1957. It aims to provide a platform for sharing knowledge in cardiology, from basic science to translational and clinical research on cardiovascular diseases.
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