{"title":"High Expression of <i>PKCζ</i> And <i>CTNNBIP1</i> Is Associated With Poor Prognosis in Luminal B Breast Cancer.","authors":"Yuka Nagashima, Kazunori Sasaki, Ryosuke Chiwaki, Hayato Ishii, Kana Nohata, Yuki Maemura, Takahiro Kasai, Ayaka Ozaki, Shoma Tamori, Shigeo Ohno, Kazunori Akimoto","doi":"10.21873/cgp.20520","DOIUrl":null,"url":null,"abstract":"<p><strong>Background/aim: </strong>The relationship between protein kinase C zeta (<i>PKCζ</i>) expression and medical treatment resistance in breast cancer subtypes is unclear. Therefore, the present study aimed to analyze this relationship using disease-specific survival.</p><p><strong>Materials and methods: </strong>Open-source datasets with clinical and gene expression information (METABRIC, n=2509; and TCGA Pan-Cancer Atlas, n=1084) were downloaded and Kaplan-Meier survival and Cox proportional hazard analyses were performed.</p><p><strong>Results: </strong>High expression of <i>PKCζ</i> indicated a poor prognosis in patients with luminal B type treated with endocrine therapy and aromatase inhibitor as endocrine therapy. Furthermore, catenin beta interacting protein 1 (<i>CTNNBIP1</i>) was identified as a differentially expressed gene between the <i>PKCζ</i> <sup>high</sup> and <i>PKCζ</i> <sup>low</sup> luminal B breast cancer cohorts treated with endocrine therapy and aromatase inhibitors. <i>PKCζ</i> <sup>high</sup> <i>CTNNBIP1</i> <sup>high</sup> luminal B breast cancer treated with endocrine therapy and aromatase inhibitor indicated a poor prognosis. These results suggest that <i>PKCζ</i> and <i>CTNNBIP1</i> are involved in breast cancer progression and contribute to reduced susceptibility to endocrine therapy in the luminal B breast cancer subtype.</p><p><strong>Conclusion: </strong><i>PKCζ</i> and <i>CTNNBIP1</i> may serve as a prognostic biomarker for predicting the efficacy of endocrine therapy in the luminal B breast cancer.</p>","PeriodicalId":9516,"journal":{"name":"Cancer Genomics & Proteomics","volume":"22 4","pages":"538-556"},"PeriodicalIF":2.6000,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer Genomics & Proteomics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.21873/cgp.20520","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 0
Abstract
Background/aim: The relationship between protein kinase C zeta (PKCζ) expression and medical treatment resistance in breast cancer subtypes is unclear. Therefore, the present study aimed to analyze this relationship using disease-specific survival.
Materials and methods: Open-source datasets with clinical and gene expression information (METABRIC, n=2509; and TCGA Pan-Cancer Atlas, n=1084) were downloaded and Kaplan-Meier survival and Cox proportional hazard analyses were performed.
Results: High expression of PKCζ indicated a poor prognosis in patients with luminal B type treated with endocrine therapy and aromatase inhibitor as endocrine therapy. Furthermore, catenin beta interacting protein 1 (CTNNBIP1) was identified as a differentially expressed gene between the PKCζhigh and PKCζlow luminal B breast cancer cohorts treated with endocrine therapy and aromatase inhibitors. PKCζhighCTNNBIP1high luminal B breast cancer treated with endocrine therapy and aromatase inhibitor indicated a poor prognosis. These results suggest that PKCζ and CTNNBIP1 are involved in breast cancer progression and contribute to reduced susceptibility to endocrine therapy in the luminal B breast cancer subtype.
Conclusion: PKCζ and CTNNBIP1 may serve as a prognostic biomarker for predicting the efficacy of endocrine therapy in the luminal B breast cancer.
期刊介绍:
Cancer Genomics & Proteomics (CGP) is an international peer-reviewed journal designed to publish rapidly high quality articles and reviews on the application of genomic and proteomic technology to basic, experimental and clinical cancer research. In this site you may find information concerning the editorial board, editorial policy, issue contents, subscriptions, submission of manuscripts and advertising. The first issue of CGP circulated in January 2004.
Cancer Genomics & Proteomics is a journal of the International Institute of Anticancer Research. From January 2013 CGP is converted to an online-only open access journal.
Cancer Genomics & Proteomics supports (a) the aims and the research projects of the INTERNATIONAL INSTITUTE OF ANTICANCER RESEARCH and (b) the organization of the INTERNATIONAL CONFERENCES OF ANTICANCER RESEARCH.