Elevated Stanniocalcin-1 Expression in Uveal Melanoma Predicts Poor Patient Prognosis.

IF 2.6 4区 医学 Q2 GENETICS & HEREDITY
Shin-Nosuke Yamashita, Yoshiatsu Tanaka, Shajedul Islam, Honoka Kotake, Maki Tanaka, Takao Kitagawa, Kazuhiro Tokuda, Durga Paudel, Sarita Giri, Tohru Ohta, Fumiya Harada, Hiroki Nagayasu, Yasuhiro Kuramitsu
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引用次数: 0

Abstract

Background/aim: Uveal melanoma (UVM) is the most prevalent primary intraocular malignancy, accounting for 3-5% of all melanomas. Despite its rarity, particularly in Japan (~2 cases per 100,000 individuals annually), UVM exhibits highly aggressive behavior, with nearly 50% of patients developing distant metastases. Once metastasized, the prognosis remains dismal, with a median survival of only 4-5 months. Identifying prognostic biomarkers and potential therapeutic targets is imperative to improve clinical outcomes. Stanniocalcin-1 (STC-1) is a glycoprotein hormone implicated in calcium and phosphate homeostasis. Recent studies have linked STC-1 overexpression to tumor progression, poor prognosis, and increased metastatic potential in various malignancies. However, the prognostic significance and mechanistic role of STC-1 in UVM remain unexplored.

Materials and methods: To elucidate the clinical relevance of STC-1 in UVM, we analyzed publicly available transcriptomic datasets using GEPIA2 and UALCAN, assessing STC-1 mRNA expression across disease stages and its correlation with patient survival. In parallel, single-cell RNA sequencing (scRNA-seq) datasets were utilized to identify the cellular sources of STC-1 within the UVM tumor microenvironment and to investigate its association with specific functional cellular states.

Results: STC-1 expression was significantly up-regulated in stage IV UVM tumors compared to stage III (n=4 and 36, respectively). Moreover, elevated STC-1 expression was inversely correlated with overall survival, suggesting its potential role in disease progression. scRNA-seq analysis revealed that STC-1 is expressed by both tumor cells and fibroblasts, indicating a possible cooperative mechanism that may drive tumor progression.

Conclusion: These findings suggest that STC-1 serves as a potential prognostic biomarker in UVM, providing novel insights into its role in tumor biology. Further investigation is warranted to explore its therapeutic implications and mechanistic contributions to UVM progression.

葡萄膜黑色素瘤中斯坦钙素-1表达升高预示患者预后不良。
背景/目的:葡萄膜黑色素瘤(UVM)是最常见的原发性眼内恶性肿瘤,占所有黑色素瘤的3-5%。尽管罕见,特别是在日本(每年每10万人中约2例),但UVM表现出高度侵袭性行为,近50%的患者发生远处转移。一旦转移,预后仍然很差,中位生存期只有4-5个月。确定预后生物标志物和潜在的治疗靶点是改善临床结果的必要条件。斯坦钙素-1 (STC-1)是一种参与钙和磷酸盐稳态的糖蛋白激素。最近的研究将STC-1过表达与各种恶性肿瘤的肿瘤进展、预后不良和转移潜力增加联系起来。然而,STC-1在UVM中的预后意义和机制作用尚不清楚。材料和方法:为了阐明STC-1在UVM中的临床相关性,我们使用GEPIA2和UALCAN分析了公开可用的转录组数据集,评估了STC-1 mRNA在疾病分期的表达及其与患者生存的相关性。同时,利用单细胞RNA测序(scRNA-seq)数据集确定UVM肿瘤微环境中STC-1的细胞来源,并研究其与特定功能细胞状态的关联。结果:STC-1在IV期UVM肿瘤中的表达较III期显著上调(n=4和36)。此外,STC-1表达升高与总生存率呈负相关,提示其在疾病进展中的潜在作用。scRNA-seq分析显示,STC-1在肿瘤细胞和成纤维细胞中均有表达,表明可能存在一种驱动肿瘤进展的合作机制。结论:这些发现表明STC-1可能是UVM的潜在预后生物标志物,为其在肿瘤生物学中的作用提供了新的见解。进一步的研究需要探索其治疗意义和UVM进展的机制贡献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cancer Genomics & Proteomics
Cancer Genomics & Proteomics ONCOLOGY-GENETICS & HEREDITY
CiteScore
5.00
自引率
8.00%
发文量
51
期刊介绍: Cancer Genomics & Proteomics (CGP) is an international peer-reviewed journal designed to publish rapidly high quality articles and reviews on the application of genomic and proteomic technology to basic, experimental and clinical cancer research. In this site you may find information concerning the editorial board, editorial policy, issue contents, subscriptions, submission of manuscripts and advertising. The first issue of CGP circulated in January 2004. Cancer Genomics & Proteomics is a journal of the International Institute of Anticancer Research. From January 2013 CGP is converted to an online-only open access journal. Cancer Genomics & Proteomics supports (a) the aims and the research projects of the INTERNATIONAL INSTITUTE OF ANTICANCER RESEARCH and (b) the organization of the INTERNATIONAL CONFERENCES OF ANTICANCER RESEARCH.
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