Contribution of MRE11, RAD50, and NBS1 Genotypes to Bladder Cancer Susceptibility.

IF 2.6 4区医学 Q2 GENETICS & HEREDITY

Cancer Genomics & Proteomics Pub Date : 2025-06-26 DOI:10.21873/cgp.20523

Cheng-Hsi Liao, Wen-Shin Chang, Hou-Yu Shih, Yun-Chi Wang, Che-Lun Hsu, Shu-Yu Chang, Chao-Hsiang Chang, Wen-Chi Chen, DA-Tian Bau, Chia-Wen Tsai

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Abstract

Background/aim: Genome instability is a hallmark of cancer, often accelerated by defects in DNA damage responses. MRE11-RAD50-NBS1 (MRN) complex plays a crucial role in sensing and repairing DNA damage; however, there is limited literature on the involvement of MRN genotypes in bladder cancer (BLCA) susceptibility. This study aimed to elucidate the impact of MRN genotypes on the risk of BLCA.

Materials and methods: We genotyped 14 single nucleotide polymorphisms (SNPs) in MRN genes, including rs684507, rs2155209, rs10831234, rs13447720, rs601341 in MRE11, rs17166050, rs17772583, rs6871536, rs3798134, rs2244012 in RAD50, and rs1805794, rs2735383, rs1063053, rs1063054 in NBS1, among 375 BLCA cases and 375 controls, and evaluated their contributions to BLCA susceptibility.

Results: Among these SNPs, only NBS1 rs2735383 was significantly associated with BLCA risk (p for trend=0.0053), with both CG and CC genotypes conferring higher risks (OR=1.48 and 1.95, respectively). Subgroup analysis showed that NBS1 rs2735383 was associated with BLCA risk in individuals older than 55 years (OR=2.29, p=0.0053), smokers (OR=2.56, p=0.0026), alcohol drinkers (OR=3.25, p=0.0005), and those with muscle-invasive disease (OR=1.97, p=0.0243), but not in younger individuals, non-smokers, non-drinkers, or non-muscle-invasive cases.

Conclusion: NBS1 rs2735383 genotype may serve as a genetic biomarker for BLCA susceptibility, particularly in high-risk subpopulations, including elders, smokers, drinkers, and those with muscle-invasive disease.

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MRE11、RAD50和NBS1基因型对膀胱癌易感性的影响

背景/目的：基因组不稳定是癌症的一个标志，通常由于DNA损伤反应的缺陷而加速。MRE11-RAD50-NBS1 （MRN）复合物在DNA损伤的感知和修复中起重要作用；然而，MRN基因型参与膀胱癌（BLCA）易感性的文献有限。本研究旨在阐明MRN基因型对BLCA风险的影响。材料与方法：在375例BLCA病例和375例对照中，对MRE11中的rs684507、rs2155209、rs10831234、rs13447720、rs601341、RAD50中的rs17166050、rs17772583、rs6871536、rs3798134、rs2244012、NBS1中的rs1805794、rs2735383、rs1063053、rs1063054等14个MRN基因单核苷酸多态性（snp）进行基因分型，并评估其对BLCA易感性的影响。结果：在这些snp中，只有NBS1 rs2735383与BLCA风险显著相关（p为趋势值=0.0053），CG和CC基因型均具有更高的风险（OR分别为1.48和1.95）。亚组分析显示，NBS1 rs2735383与55岁以上人群（OR=2.29, p=0.0053）、吸烟者（OR=2.56, p=0.0026）、饮酒者（OR=3.25, p=0.0005）和肌肉侵袭性疾病患者（OR=1.97, p=0.0243）的BLCA风险相关，但与年轻人、非吸烟者、非饮酒者或非肌肉侵袭性病例无关。结论：NBS1 rs2735383基因型可作为BLCA易感性的遗传生物标志物，特别是在高危亚人群中，包括老年人、吸烟者、饮酒者和肌肉侵袭性疾病患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Genomics & Proteomics ONCOLOGY-GENETICS & HEREDITY

CiteScore

5.00

自引率

8.00%

发文量

期刊介绍： Cancer Genomics & Proteomics (CGP) is an international peer-reviewed journal designed to publish rapidly high quality articles and reviews on the application of genomic and proteomic technology to basic, experimental and clinical cancer research. In this site you may find information concerning the editorial board, editorial policy, issue contents, subscriptions, submission of manuscripts and advertising. The first issue of CGP circulated in January 2004. Cancer Genomics & Proteomics is a journal of the International Institute of Anticancer Research. From January 2013 CGP is converted to an online-only open access journal. Cancer Genomics & Proteomics supports (a) the aims and the research projects of the INTERNATIONAL INSTITUTE OF ANTICANCER RESEARCH and (b) the organization of the INTERNATIONAL CONFERENCES OF ANTICANCER RESEARCH.